急性百草枯中毒临床研究进展

百草枯是农业生产中广泛使用的一种除草剂,有较强的毒性。因百草枯中毒发病初期症状不典型,无特效解毒剂及后期不可逆转的肺纤维化已使其成为目前致死性最高的农药中毒。目前研究认为中毒损伤机制主要是通过其强氧化作用,使机体内还原酶及脂质的氧化,直接或间接损伤DNA,使细胞坏死或凋亡。提高救治成功的关键是加强基层医护人员对该病的认知水平,在服毒后第一时间及时行失活与吸附处置;进行强化血液灌流,合理应用免疫抑制剂和抗自由基、炎性介质药物。

Research Progress in Acute Paraquat Poisoning

Paraquat,which is used widely as a potent herbicide,is poisonous.Paraquat poisoning has caused a large number of human fatalities because there is no typical symptom in the early stage and there is no pharmacological antagonists or chelating agents.Studies show that it is so strong an oxidant that it can oxidate lipid and some enzyme,also,it can damage DNA directly or induce necrosis apoptosis.The most important step of paraquat poisoning treatment is to enhance the knowledge of its treatment strategy in me...