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治疗性单克隆抗体研究新进展
引用本文:贾建桃,马丽菊,王秦秦.治疗性单克隆抗体研究新进展[J].医学综述,2007,13(5):325-327.
作者姓名:贾建桃  马丽菊  王秦秦
作者单位:1. 长治医学院病理生理学教研室,山西,长治,046000
2. 昆明医学院第一附属医院临床医学实验研究中心,昆明,650032
摘    要:治疗性单克隆抗体的快速发展在人类以肿瘤为主的多种疾病的治疗方面发挥至关重要的作用。为了降低鼠源抗体引起的超敏反应,治疗性单克隆抗体已由改型抗体,人源化抗体发展到全人抗体。随着生物技术的不断发展,相信人源化单克隆抗体的前景会越来越广泛。

关 键 词:单克隆抗体  人源化  人源化抗体  治疗
文章编号:1006-2084(2007)05-0325-03
收稿时间:2006-06-17
修稿时间:2007-01-21

Study Progress of Remedial Monoclonal Antibody
JIA Jian-tao,MA Li-ju,WANG Qin-qin.Study Progress of Remedial Monoclonal Antibody[J].Medical Recapitulate,2007,13(5):325-327.
Authors:JIA Jian-tao  MA Li-ju  WANG Qin-qin
Institution:1. Department of Pathophysiology of Changzhi Medical Colledge , Changzhi 046000, China ; 2 Research Center of Clinical Medicine, the First Affiliated Hospital of Kunming Medical College, Kunming 650032, China
Abstract:The rapid development of therapeutic McAbs plays a crucial effect in treating many kinds of human diseases,especially in treating tumor.Therapeutic mAbs has developed from reshaping antibody and humanized antibody to fully human antibody in order to lower supersensitivity resulting from mouse antibody.With the going forward of biotechnology,humanized antibody will has a more and more wide perspective.
Keywords:Monoclonal antibody  Humanize  Humanized antibody  Therapy
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