中药逆转肿瘤多药耐药作用的研究现状

肿瘤的多药耐药(MDR)是导致肿瘤化疗失败的最常见因素,已成为治疗肿瘤的一大障碍,但是目前所用的MDR逆转剂临床效果欠佳,寻找有效的肿瘤MDR逆转剂已成为医学界的一大热点。中药配合放化疗已有数十年的历史,积累了较多的经验,在中药中筛选MDR逆转剂具有很大的潜力。近年来从中药中发现了许多种具有逆转肿瘤MDR作用的活性成分,现对其逆转肿瘤MDR的作用机制予以综述。

Traditional Chinese Medicine in Reversal of Multi-drug Resistance

The multi-drug resistance( MDR) is the most common cause of chemotherapy failure, as a major obstacle of cancer therapy. Looking for an effective and clinically applicable regimen has become a hotspot of the research in reversing MDR. However,the clinical effects of MDR reversal agents are poor while the traditional Chinese medicine combined with chemotherapy has decades of history and accumulated more experience. Screening MDR reversal agents in traditional Chinese medicines has great potential. In recent years,many kinds of agents from traditional Chinese medicines have been found active in reversing MDR. The mechanisms of reversing MDR were mainly reviewed in this article.