胰岛素类似物:糖尿病治疗的新选择

胰岛素类似物是一种新型的胰岛素,它们是通过DNA重组技术而产生的,与人的胰岛素结构只有很小的差别。目前有三种胰岛素类似物:速效(超短效)胰岛素类似物、长效胰岛素类似物、预混胰岛素类似物。速效胰岛素类似物可应用于餐后2h血糖较高的患者,并且可以注射后立即用餐,不必等待30min;长效胰岛素类似物可作为基础胰岛素应用,降低空腹血糖,可以替代胰岛素泵的基础量;预混胰岛素类似物是速效胰岛素类似物与鱼精蛋白胰岛素类似物的混合制剂(25:75或30:70),它可同时发挥速效胰岛素类似物和鱼精蛋白胰岛素类似物的功能,每天需要2次注射,可以控制全天的血糖水平。因此,胰岛素类似物的开发利用,为糖尿病的治疗提供了新选择。

Insulin Analogues: The New Choice for Diabetes Therapy

Insulin analogues are a kind of neotype insulin, which are produced by DNA recombinated technique having little difference with human insulin. Now there are three kinds of analogues with immediate effect, long-acting and premix style. The short-acting analogues are used in some diabetes patients with higher P2BG, meanwhile,the short-acting analogue is injected just before the meal, needless to wait for 30 minutes.The long-acting analogues could be used as basic treatment of insulin,once per day,it could not only decrease the FPG,but also replace the basic dosage of insulin pump. The premixed analogues are the mixture of short-acting insulin anologues and protamine insulin analogues in the ratio about 25to 75 or 30 to 70, which can play its effects like short-acting and protamine insulin analogues simultaneously. It need twice injection per day in order to control the blood glucose level in whole day. So the exploitation and utilization of these analogues will provide the new choice for diabetes therapy.