| EB病毒感染与宿主细胞恶性转化的关系 |
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| 引用本文： | 罗春艳,甘润良.EB病毒感染与宿主细胞恶性转化的关系[J].医学综述,2009,15(11):1613-1617. |
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| 作者姓名： | 罗春艳 甘润良 |
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| 作者单位： | 南华大学医学院肿瘤研究所,湖南,衡阳,421001 |
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| 摘 要： | EB病毒(EBV)是一种与多种肿瘤发生密切相关的DNA肿瘤病毒。EBV基因表达产物有潜伏膜蛋白(LMP1、LMP2A、LMP2B),6种核抗原(EBNA1、EBNA2、EBNA3A、EBNA3B、EBNA3C、EBNA-LP),以及EBER1、EBER2和TP等。EBV通过影响和调控宿主细胞基因的表达,干扰细胞信号转导系统,使宿主细胞产生细胞因子表达失衡。EBV能上调IRF-4、IL-6、Bcl-6、Bcl-2、A20等细胞生长因子、抗凋亡因子,还能抑制p53和PTPPK等肿瘤抑制基因,促使宿主细胞转化为肿瘤细胞。
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| 关 键 词： | EB病毒 癌细胞 恶性转化 |
Correlation of EB Virus Infection with Malignant Transformation of Host Cells |
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| LUO Chun-yan,GAN Run-liang.Correlation of EB Virus Infection with Malignant Transformation of Host Cells[J].Medical Recapitulate,2009,15(11):1613-1617. |
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| Authors: | LUO Chun-yan GAN Run-liang |
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| Institution: | LUO Chun-yan, GAN Run-liang. (Cancer Research Institute,Medical Collgeg,Nanhna University,Hengyang 421001 ,China) |
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| Abstract: | EB virus（EBV） is a kind of DNA tumor virus which is related to many kinds of tumors. The products of EBV gene contain a lot of substances, such as the latent membrane protein （LMP1, LMP2A, LMP2 B ）, 6 kinds of nuclear antigen （ EBNA 1, EBNA2, EBNA3 A, EBNA3 B, EBNA3 C, EBNA-LP） , EBER1, EBER2,TP and so on. By affecting host cell gene expression and disturbancing cell signal conduction system, EBV causes the host cell to have unbalanced cell factor expression. EBV can up-regulate some kinds of cell growth factors and anti-apoptotic genes including IRF-4, IL-6, Bcl-6, Bcl-2, A20 and so on. EBV also can down-regulate P53, PTPPK and other tumor-suppressing genes. |
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| Keywords: | EB virus Tumour cell Malignant transformation |
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