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治疗性疫苗的研究进展
引用本文:欧霞.治疗性疫苗的研究进展[J].医学综述,2012,18(17):2844-2846.
作者姓名:欧霞
作者单位:中国医学科学院,北京协和医学院,医学生物学研究所分子生物研究室,昆明,650118
摘    要:治疗性疫苗主要是通过打破机体的免疫耐受,提高机体的特异性免疫反应,对一些目前尚无有效治疗药物的疾病起到治疗作用。它不仅具有传统疫苗的一般功能,而且能够用于临床患者的治疗,因此治疗性疫苗研究近年来得到了很大的发展,临床数据表明治疗性疫苗在肿瘤、高血压和乙型肝炎等慢性复发性感染等疾病方面具有不同程度的疗效。现从治疗性疫苗的概念以及与传统疫苗的比较、作用机制、研究应用等方面进行介绍。

关 键 词:治疗性疫苗  肿瘤疫苗  乙型肝炎疫苗  高血压疫苗  作用机制  临床应用

Research Progress of Therapeutic Vaccine
OU Xia.Research Progress of Therapeutic Vaccine[J].Medical Recapitulate,2012,18(17):2844-2846.
Authors:OU Xia
Institution:.(Department of Molecular Biology,Institute of Medical Biology,Chinese Academy of Medical Science,Peking Union Medical College,Kunming 650118,China)
Abstract:Compared to traditional vaccine,the therapeutic vaccine is an efficient new technique on treatment of chronic infection disease and tumor by breaking up immunological tolerance and stimulating specific immune response,to treat the diseases which so far have no effective therapeutic medicine.It not only has the function of the conventional vaccine,but is also applicable in the treatment,therefore great progress has been made in its research in recent years.Clinical data have shown that therapeutic vaccines have different degrees of therapeutic effects in the chronic and recuurent infectious diseases such as tumor,hypertension and hepatitis B.Here is mainly to introduce the differences between the therapeutic vaccine and traditional vaccine,the mechanism of action and the recent clinical applications.
Keywords:Therapeutic vaccine  Cancer vaccine  Hepatitis B virus vaccine  Hypertension vaccine  Mechanism  Clinical application
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