| 类风湿性关节炎滑膜新生血管形成及抑制机制 |
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| 引用本文： | 成锋,王昌兴,王伟东.类风湿性关节炎滑膜新生血管形成及抑制机制[J].医学综述,2009,15(15):2291-2294. |
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| 作者姓名： | 成锋 王昌兴 王伟东 |
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| 作者单位： | 1. 浙江中医药大学,杭州,310053
2. 浙江中医药大学附属第二医院骨科,杭州,310005 |
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| 基金项目： | 浙江省中医药青年课题资助项目 |
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| 摘 要： | 类风湿性关节炎(RA)是一种慢性炎症性疾病,关节滑膜增生并形成血管翳是其重要特征;增生的滑膜需要更多的血供以满足其对氧气和营养物质的需求,因而血管新生在血管翳的形成和维持方面起着关键的作用。鉴于血管翳是高度血管化的,抑制RA中血管新生可能会成为未来治疗RA的有效策略。本文对近年生成及抑制新生血管形成的机制研究予以综述。
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| 关 键 词： | 血管新生 血管内皮生长因子 滑膜炎 类风湿性关节炎 |
Research Progress of Synovium Neovascularization and its Inhibitory Mechanism in Rheumatoid Arthritis |
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| CHENG Feng,WANG Chang-xing,WANG Wei-dong.Research Progress of Synovium Neovascularization and its Inhibitory Mechanism in Rheumatoid Arthritis[J].Medical Recapitulate,2009,15(15):2291-2294. |
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| Authors: | CHENG Feng WANG Chang-xing WANG Wei-dong |
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| Institution: | CHENG Feng , WANG Chang-xing, WANG Wei-dong ( 1. Zhejiang Chinese Medical Univeisity ,Hangzhou 310053, China; 2. Department of Orthopaedic ,the Second Affiliated Hospital to Zhejiang Chinese Medical Univeisity , Hangzhou 310005, China ) |
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| Abstract: | Rheumatoid arthritis （RA） is a kind of chronic inflammatory disease characterized by hyperplasia of synovium and pannus formation. As more oxygen and nutrition are need in synovium hyperplasia, the generation of new vessels is important in pannus generation. Inhibiting new generated vessels may be of efficiency in future treatment of RA with hyper-vascularized pannus. This paper reviewed the research progress of formation and inhibition of new vessels in RA. |
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| Keywords: | Generation of new vessels Vascular endothelial growth factor Synovitis Rheumatoid arthritis |
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