冠心病患者血清胱抑素C和胆红素测定及其临床意义

目的:探讨血清胱抑素C和胆红素在冠心病患者中的含量以及对评估冠心病病情的临床意义。方法:将320例经冠状动脉造影证实为冠心病的患者根据病变冠脉支数的不同分为单支病变组128例,双支病变组110例和多支病变组82例,对照组80例为冠脉正常者,测定各组血清胱抑素C、胆红素以及血脂水平。结果:从对照组到多支病变组,随着病变冠脉支数的增多,血清胱抑素C含量,血脂TC、TG、LDL-C出现不同程度的升高(P<0.05);血清胆红素、HDL-C则出现明显的下降(P<0.05)。结论:血清胱抑素C和胆红素可以作为评估冠状动脉粥样硬化严重程度的敏感指标,指导临床诊断和治疗。

Cystatin c and bilirubin changes and its clinical significance in patients with CHD

Objective： To detective the clinical significance of serum cystatin C and bilirubin levels in pa tients with coronary heart disease. Methods： 320 cases CHD divided into 3 groups based on different lesions in coro nary count, 128 cases in single-vessel disease group, 110 cases in double-vessel disease group and 82 cases in multi- vessel disease group. The control group had 80 cases with normal coronary. Determined the serum cystatin C, bill rubin, and lipid levels. Results： From the control group to multi-vessel disease group, with the coronary lesion count increase, serum cystatin C levels, TC, TG and LDL-C increased significantly; serum bilirubin, HDL-C de creased significantly. Conclusion ： Serum cystatin C and bilirubin can be used to assess the severity of coronary ather osclerosis as a sensitive indicators.