| MMP-9、bcl-2基因与胃癌相关性研究 |
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| 引用本文： | 袁景孝,曹罡.MMP-9、bcl-2基因与胃癌相关性研究[J].陕西医学杂志,2007,36(9):1235-1237. |
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| 作者姓名： | 袁景孝 曹罡 |
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| 作者单位： | 1. 陕西省白水县医院外一科,白水,715600
2. 西安交通大学医学院第二附属医院 |
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| 摘 要： | 目的:探讨基质金属蛋白酶-9(MMP-9)、细胞凋亡抑制基因(bcl-2)在胃癌组织中的表达及其相关性分析。方法:利用免疫组化S-P法检测60例胃癌组织及20例癌旁正常组织中MMP-9、bcl-2的表达。结果:MMP-9的表达与肿瘤细胞的分化程度及临床病理分期密切相关(P<0.05),bcl-2的表达与胃癌的临床病理分期及细胞分化程度无显著性差异(P>0.05),MMP-9与bcl-2表达无明显相关性。结论:MMP-9、bcl-2表达与胃癌生物学行为之间关系密切。
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| 关 键 词： | 胃肿瘤/病理学 明胶酶B/代谢 基因 bcl-2/代谢 |
| 修稿时间： | 2007-03-10 |
Correlative study between expression of MMP-9,bcl-2 and biological behavior of gastric carcinoma |
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| Yuan Jingxiao,Cao Gang.Correlative study between expression of MMP-9,bcl-2 and biological behavior of gastric carcinoma[J].Shaanxi Medical Journal,2007,36(9):1235-1237. |
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| Authors: | Yuan Jingxiao Cao Gang |
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| Institution: | Baishui 715600 |
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| Abstract: | Objective:To investigate the relationship between the biological behavior of gastric carcinoma and the expressions of matrix metalloproteinase-9,bcl-2 in the gastric carcinoma tissues.Methods:60 samples of gastric carcinoma and 20 nomal specimens of para-carcinoma were assessed by immunohistochemical S-P.Results: Expression of MMP-9 was closely correlated with differention and clinicopathological stage of the tumor cells(P<0.05) and bcl-2 had no obvious collelation with differenation and clinicopathological stage of gastric carcinoma(P>0.05).Conclusion:Expression of MMP-9 and bcl-2 are closely correlated with biological behavior of gastric carcinoma. |
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| Keywords: | Stomach neoplasms/pathology Gelatinase B/metabolism Genes bcl-2/metabolism |
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