神经节苷脂治疗新生儿缺氧缺血性脑病42例

目的:探讨单唾液酸四己糖神经节苷脂(GM1)治疗新生儿缺氧缺血性脑病(HIE)的疗效。方法:将83例HIE患儿随机分为治疗组和对照组,均给予常规治疗,治疗组在此基础上应用GM1,每次20mg,每天1次,10~14d为1个疗程。通过比较两组患儿神经症状恢复时间和新生儿行为神经评分(NBNA)来判断药物疗效。结果:治疗后两组患儿神经症状恢复时间和NBNA评分经统计学处理,均具有显著性差异(P<0.05),治疗组疗效优于对照组。结论:GM1治疗HIE疗效好,能促进临床症状缓解,缩短病程,提高治愈率。

Observation of clinical curative effect of ganglioside for 42 neonate with hypoxic ischemic encephalopathy

Objective:To explore the curative effect of monosialotetrahexosyl ganglioside for treating neonatal hypoxic ischemic encephalopathy(HIE). Methods: 83 cases of HIE were divided into treatment group and control group randomly,and both groups received conventional therapy. Injection of ganglioside was added in the treatment group , 20mg each time, 10～14 days as a course of treatment。After treatment,the neonate were evaluated by recovery time of nerve symptom recovery and NBNA. Results: Treatment group surpasses control group in recovery time of nerve symptom recovery and NBNA ,there is significant difference between two groups(P<0.05).Conclusion : GM1 can relieve clinical symptom ,shorten course of disease and increase cure rate , GM1 has ideal curative effect on neonatal HIE.