疏血通对急性冠脉综合征介入治疗术后的影响

目的:观察疏血通对急性冠脉综合征(ACS)患者介入治疗(PCI)前后内皮功能、纤溶活性的影响,并探讨疏血通治疗与PCI治疗后早期心脏相关并发症的关系。方法:选择2006年3月至2008年1月在我院心导管室行PCI治疗的84例患者为研究对象,PCI术后随机分为两组,对照组给予常规治疗,疏血通组在常规治疗基础上于术后第1天加用疏血通静滴1周。所有患者于PCI前1天、术后1周分别测定血浆纤溶酶原激活物(t-PA)、抑制物(PAI-I)、假性血友病因子(vWF)的影响,并观察心脏事件发生率。结果:疏血通组患者血浆vWF和PAI-I水平降低,而t-PA活性增加,与对照组比较有显著差异(P<0.05),并且疏血通组与对照组相比心脏事件发生率有降低的趋势(P<0.05)。结论:ACS患者PCI术后应用疏血通可以改善内皮功能和纤溶活性,减少心脏事件的发生。

Effects of shuxuetong on acute coronary syndrome patients after interventional thearpy

Objective： To investigate the effects of shuxuetong on endothelial function and fibrinolysis activities of acute coronary syndrome（ACS） patients after interventional therapy and its early heart complication. Methods： t-PA, PAI-I and vWF were measured in 50 patients in therapy group and 34 patients of control group. Results： The levels of serum PAII and vWF in therapy group were lower, and the level of serum t PA was higher compared with that control group （P〈0. 05）. The rate of early heart complication of therapy group was lower compared with in control group（P〈0.05）. Conclusion： Shuxuetong can improve the endothelia function and fibrinolysis activities, and decrease the rate of early heart complication in ACS patients after interventional therapy.