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吸烟对健康青年人群循环内皮细胞的作用
引用本文:马世玉,向继洲,胡本容,马业新.吸烟对健康青年人群循环内皮细胞的作用[J].陕西医学杂志,2005,34(4):409-411.
作者姓名:马世玉  向继洲  胡本容  马业新
作者单位:1. 华中科技大学同济医学院附属同济医院心内科,武汉,430030
2. 华中科技大学同济医学院药理学系
基金项目:湖北省重点科技攻关项目资助 (No.2 0 0 2 AA3 0 5 B0 8)
摘    要:目的:探讨吸烟对健康青年人群循环内皮细胞及血浆一氧化氮( NO)和内皮素( ET)的影响。方法:选取健康吸烟者85例(轻型37例,重型48例) ,健康不吸烟者1 2 8例。按Hladovec法检测循环内皮细胞( CEC)的数量,同时采用比色法和放射免疫方法测定青年人群血浆中NO和ET- 1含量,并计算NO/ET的比值。结果:健康青年吸烟者的CEC数量和血浆ET- 1含量均较不吸烟者显著增高,而血浆中NO含量明显下降,NO/ET比值亦较不吸烟者降低。结论:健康吸烟的青年人群中内皮细胞结构和功能在心、脑血管疾病发生之前已经发生损害,应引起高度重视。

关 键 词:一氧化氮/血液  内皮缩血管肽1/血液  @循环内皮细胞  吸烟

Effects of cigarette smoking on circulating endothelial cell in healthy young people
Institution:Wuhan 430030
Abstract:Objective: To investigate the effects of cigarette smoking on circulating endothelial cell, and the levels of endothelin-1 (ET-1) and nitric oxide (NO) of plasma in healthy young men. Methods:Male graduates of health examination in a college were adopted as investigative objectives including 85 normal smokers (including 37 slight cases and 48 moderate cases) and 128 normal non-smokers as controls. The circulating endothelial cells (CEC) were counted and contents of ET-1 as well as NO of plasma were delermined by radioimmunoassay and spectrophotometer analysis respectively. Results: The number of CEC and the level of plasma ET-1 in smoking groups were significantly higher than that of the non-smoking group. And the contents of NO and the ratios of NO/ET were dramatically decreased in the smoking groups. Conclusion: Cigarette smoking significantly damages the structure and function of vascular endothelial cells before the cardiovascular and cerebral diseases happening in healthy young people.
Keywords:Nieric oxide/blood  Endothelin-1/blood  @Circulating endothelial cell  Somking
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