| 脑外伤患者血浆NSE,ET-1的检测及其与近期预后的关系 |
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| 引用本文： | 王红斌,智华,朱庆华,王丽梅,王静,马东周.脑外伤患者血浆NSE,ET-1的检测及其与近期预后的关系[J].陕西医学杂志,2011,40(9):1215-1218. |
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| 作者姓名： | 王红斌 智华 朱庆华 王丽梅 王静 马东周 |
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| 作者单位： | 河北工程大学附属医院神经外科,邯郸,056029 |
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| 基金项目： | 河北省邯郸市科技局基金 |
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| 摘 要： | 目的:探讨NSESE和ET-1与脑外伤严重程度以及与近期预后的关系。方法:对48例脑外伤患者于伤后第1、3、7天分别采集静脉血3ml,同时选取我院健康体检者25例为对照组并采集静脉血3ml,用放免法检测NSE和ET-1水平,对所得资料进行统计学分析。结果:脑外伤患者血浆NSE、ET-1水平显著高于对照组(P<0.05)。脑外伤后不同时期的检测结果显示,重度脑外伤组的血浆NSE、ET-1水平明显高于轻中度脑外伤组(P<0.05)。预后不良组与对照组不同时间点测量的血浆ET-1数值不同,两组间有显著性差异(P<0.05)。预后不良组较预后良好组明显升高(P<0.05)。伤后1周内,二者的血浆水平均逐渐升高,颅脑损伤越重血浆ET-1浓度越高,NSE升高的程度相对较轻。脑外伤病人在外伤后迅速出现血清中NSE浓度的升高比ET-1升高的更早更加敏感。结论:血浆NSE、ET-1的检测可以协助诊断脑外伤,脑外伤后血浆NSE、ET-1水平升高幅度与脑外伤损伤程度、病程发展及近期预后密切相关。颅脑损伤越重患者血浆ET-1浓度越高,NSE升高的程度较轻;NSE比ET-1更早更敏感,ET-1比NSE更持久更特异。
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| 关 键 词： | 脑损伤/诊断 脑损伤/血液 磷酸丙酮水合酶/代谢 内皮液血管肽-/代谢 预后 放射免疫测定 |
The brain external injury the relation of the blood plasma NSE and ET-1 change with brain injury degree and prognosis relation |
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| Wang Hongbin Zhi Hua Zhu Qinghua et al.The brain external injury the relation of the blood plasma NSE and ET-1 change with brain injury degree and prognosis relation[J].Shaanxi Medical Journal,2011,40(9):1215-1218. |
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| Authors: | Wang Hongbin Zhi Hua Zhu Qinghua |
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| Institution: | Wang Hongbin Zhi Hua Zhu Qinghua et alDepartment of Neurosurgery,Affiliated Hospital of Hebei Engineer University(Handan 056029) |
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| Abstract: | Objective:To study the different degree brain injury an empress the densityvariety of the blood plasma NSE ET-1 originally,study the ET-1 and the brain external injury severity degree with in the near future relation after prepare.Methods: The patients of brain external injury gave ordinary check and therapy.Choosed to collect the vein blood 3ml respectively the first day,the third day,the seventh day.The healthy-check patients as health control groups to collect the vein blood 3ml.The serum levels of NSE a... |
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| Keywords: | Brain injuries/diagnosis Brain injuries/blood Phosphopyruvate hydratase/metabolism Endothelin-1/metabolism Prognosis Radioimmunoassay |
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