子宫内膜异位症患者子宫内膜VEGF及其与血清CA125、TNF-a水平的关系

目的：探讨子宫内膜异位症患者子宫内膜VEGF及其与血清CA125、TNF-a水平的关系。方法方便收集2016年5—9月于福建医科大学附属协和医院接受治疗的子宫内膜异位症患者59例(观察组)及同期非子宫内膜异位症妇科疾病患者45例(对照组),检测观察组在位子宫内膜、异位子宫内膜及对照组在位子宫内膜的VEGF水平,比较两组的血清CA125和TNF-a水平,分析观察组子宫内膜VEGF水平与血清CA125、TNF-a水平的关系。结果观察组总体及Ⅰ~Ⅱ、Ⅲ~Ⅳ期的在位内膜中VEGF水平分别为(9.37±1.63)、(10.03±2.06)pg/mL和(7.15±1.82)pg/mL,与对照组的差异无统计学意义(P>0.05)；与对照组在位内膜相比,观察组总体及Ⅰ~Ⅱ、Ⅲ~Ⅳ期的异位内膜中VEGF水平分别为(29.63±4.25)、(26.54±2.94)pg/mL和(34.15±3.47)pg/mL,血清CA125水平分别为(46.03±3.62)、(52.84±4.15)U/mL和(37.26±3.27)U/mL,血清TNF-a水平分别为(37.48±2.77)、(29.21±2.90)pg/mL和(44.17±3.52)pg/mL,均高于对照组的(8.21±1.49)pg/mL、(13.19±2.64)U/mL和(14.56±1.73)pg/mL,差异均有统计学意义(P<0.05)；观察组在位内膜不同VEGF水平间血清CA125和TNF-a水平的差异无统计学意义(P>0.05),且在位内膜VEGF水平与血清CA125和TNF-a水平无相关性(P>0.05)；观察组异位内膜总体及不同分期的VEGF高水平组的血清CA125和TNF-a水平均高于低水平组,差异有统计学意义(P<0.05),且异位内膜VEGF水平与血清CA125和TNF-a水平呈正相关(P<0.05)。结论子宫内膜异位症患者异位子宫内膜VEGF水平升高,且与血清CA125、TNF-a水平呈正相关。

Relationship between Endometrium Level of VEGF and Serum Levels of CA125 and TNF-a in Patients with Endometriosis

Objective To explore the relationship between endometrium level of VEGF and serum levels of CA125 and TNF-a in patients with endometriosis. Methods Convenient selection 59 patients with endometriosis treated in Union Hos-pital of Fujian Medical University from May to September 2016 were collected as observation group. Besides, 45 cases of gynecological diseases without endometriosis in the same period were collected as control group. The VEGF levels in the eutopic and ectopic endometrium of observation group and the eutopic endometrium of control group were detected. The serum levels of CA125 and TNF-a were compared between both groups. The relationship between the level of VEGF and serum TNF-a and CA125 were analyzed in the observation group. Results The endometrium levels of VEGF were (9.37 ± 1.63),(10.03±2.06)pg/mL and (7.15±1.82)pg/mL in the total and different stages (Ⅰ~Ⅱ/Ⅲ~Ⅳ) of the observation group, similar with control group(P>0.05). The ectopic endometri-um levels of VEGF were(29.63±4.25),(26.54±2.94)pg/mL and (34.15 ±3.47)pg/mL,serum levels of TNF-a were (46.03±3.62),(52.84±4.15)U/mL and (37.26±3.27)U/mL, serum levels of CA125 were (37.48±2.77),(29.21±2.90)pg/mL and(44.17±3.52)pg/mL in the total and different stages (Ⅰ~Ⅱ/Ⅲ~Ⅳ) of the observation group, higher than (8.21±1.49)pg/mL,(13.19±2.64)U/mL and(14.56±1.73)pg/mL of the con-trol group (P<0.05). In the observation group, there was no significant difference in the serum levels of CA125 and TNF-a between patients with different VEGF levels(P>0.05). No correlation was observed between the level of VEGF in eutopic en-dometrium and the serum levels of TNF-a and CA125 (P>0.05). Compared with the patients with low level VEGF in obser-vation group, there were higher serum levels of CA125 and TNF-a in patients with high level VEGF (P<0.05). Serum levels of CA125 and TNF-a were positively correlated with the level of VEGF in ectopic endometrium(P<0.05). Conclusion The level of VEGF in the ectopic endometrium of patients with endometriosis is increased, and positively correlated with the serum levels of TNF-a and CA125.