丁苯酞胶囊联合艾司西酞普兰治疗卒中后抑郁的临床探讨

目的探讨丁苯酞胶囊联合艾司西酞普兰治疗卒中后抑郁短期疗效临床观察。方法 80例卒中后抑郁患者,随机分为丁苯酞胶囊联合艾司西酞普兰治疗组（实验组）40例和单用艾司西酞普兰治疗组（对照组）40例,疗程12周,采用汉密尔顿抑郁量表（HAMD）评价临床疗效。结果两组治疗12周以后HAMD评分与同组治疗前相比差异有统计学意义（P〈0.01）;治疗12周以后实验组有效率高于对照组,两组有效率及HAMD总分差异有统计学意义（P〈0.01）。结论丁苯酞胶囊联合艾司西酞普兰治疗治疗卒中后抑郁比单用艾司西酞普兰治疗临床疗效更加确切。

The Efficacy Study of Combined Treatment with dl-3-butylphthalide and Escitalopram in Post-stroke Depression

Objective To investigate the short-term efficacy of combined treatment with dl-3-butylphthalide and escitalopram in post-stroke depression. Methods Patients with post-stroke depression（n=80） were randomly divided into dl-3-butylphthalide and escitalopram group（experimental group, n=40） and single escitalopram group（control group, n=40）. The treatment course was 12 weeks. The clinical efficacy was measured by the Hamilton depression scale（HAMD）. Results After 12 weeks of treatment, the HAMD score of both groups were better than their scores before treatment with statistically significant difference（P〈0.01）; the effective rate of the experimental group was higher than that of the control group; the difference in effective rate and total HAMD score between the two groups was statistically significant（P〈0.01）. Conclusion The clinical efficacy of dl-3-butylphthalide combined with escitalopram in the treatment of post-stroke depression is more definite than that of single escitalopram.