探讨两种茶碱类药物对高龄支气管哮喘急性发作患者肺部症状、通气功能及不良反应的影响

目的：探讨氨茶碱和多索茶碱对高龄支气管哮喘急性发作患者肺部症状、通气功能及不良反应的影响。方法研究对象方便选取该院2011年1月—2015年12月收治高龄支气管哮喘急性发作患者共100例,以随机区组法分为氨茶碱组(50例)和多索茶碱组(50例),分别采用氨茶碱和多索茶碱静脉滴注治疗；比较两组患者临床疗效,症状体征改善时间,治疗前后肺通气功能指标水平及不良反应发生率等。结果氨茶碱组和多索茶碱组患者治疗总有效率分别为76.00%,94.00%；氨茶碱组患者治疗后FEV1、PEF及FEV1/FVC水平分别为(3.09±1.02)L,(5.14±1.17)L/s,(63.10±14.97)%；多索碱组患者治疗后FEV1、PEF及FEV1/FVC水平分别为(3.74±1.15)L,(5.97±1.42)L/s,(74.55±17.74)%；多索茶碱组患者临床疗效、症状体征改善时间及治疗后肺部通气功能指标水平均显著优于氨茶碱组(P<0.05)；同时氨茶碱组和多索茶碱组患者不良反应发生率分别为22.00%,6.00%；多索茶碱组患者不良反应发生率显著低于氨茶碱组(P<0.05)。结论多索茶碱治疗高龄支气管哮喘急性发作临床疗效及安全性均优于氨茶碱,具有临床应用价值。

Effects of Two Kinds of Theophylline drug on Pulmonary Symptoms,Venti-lation Function and Adverse Reactions of Elderly Patients with Acute Bronchial Asthma

Objective To investigate the effects of aminophylline and doxofylline on pulmonary symptoms, ventilation func-tion and adverse reactions of elderly patients with acute bronchial asthma. Methods Convenient selection 100 elderly pa-tients with acute bronchial asthma in the period from January 2011 to December 2015 in our hospital were chosen and ran-domly divided into two groups including aminophylline group (50 patients) with aminophylline and doxofylline group (50 patients) with doxofylline; and the clinical efficacy, the improving time of symptoms and signs, the pulmonary ventilation function index level before and after treatment and incidence of adverse reactions of both groups were compared. Results The clinical total efficacy of aminophylline group and doxofylline group were separately 76.00%,94.00%;the levels of FEV1, PEF and FEV1/FVC of aminophylline group after treatment were separately (3.09±1.02)L,(5.14±1.17)L/s,(63.10± 14.97)%; the levels of FEV1, PEF and FEV1/FVC of doxofylline group after treatment were separately (3.74 ±1.15)L, (5.97±1.42)L/s,(74.55±17.74)%;The clinical efficacy, the improving time of symptoms and signs and the pulmonary venti-lation function index level after treatment of doxofylline group after treatment was significant better than aminophylline group (P<0.05). The incidence of adverse reactions of aminophylline group and doxofylline group were separately 22.00%, 6.00%; the incidence of adverse reactions of doxofylline group were significant lower than aminophylline group (P<0.05). Conclusion Doxofylline in the treatment of elderly patients with acute bronchial asthma possess the better clinical effects and safety.