氨溴索辅助治疗胎粪吸入综合征的疗效观察

目的观察静脉注射沐舒坦对胎粪吸入综合征（MAS）的疗效。方法对25例确诊新生儿胎粪吸入综合征且需要呼吸机治疗的患儿随机分为治疗组和对照组,治疗组给予盐酸氨溴索（30mg/kg·d）,对照组给予生理盐水,用药时间为7d。观察用药后12h、24h、36h、48h、72h、96h、120h、分别记录各研究对象MAP、PaO2/FiO2的结果,并记录各研究对象的机械通气时间。结果治疗组与对照组的MAP和PaO2/FiO2在用药后48h、72h、84h差异有统计学意义（P〈0.05）。2组的平均机械通气时间有统计学差异（P〈0.05）。结论氨溴索在用药48h后能明显改善胎粪吸入患儿的肺通气和换气功能并降低机械通气时的平均气道压,能够缩短机械通气时间。

The Effect of Ambroxol by Intravenous Injection to Cure Meconium Aspiration Syndrome.

Objective To observe the effect of Ambroxol to cure meconium aspiration syndrome（MAS） by intravenous injection.Methods 25 newborns finally diagnosed MAS and requiring curing by breathing machine were divided into treat group and control group.The newborns of treat group were given Ambroxol（30mg/kg·d）,but that of control group were given normal saline.The medication time was 7 days.Then we observed MAP,PaO2/FiO2 of every object at the each time point 12h,24h,36h,48h,60h,72h,84h after given medication.The Lime of using breathing machine was also recorded in every group. Results There was significant difference between the two groups for MAP, PaO2/FiO2 at60h,72h,84h,after administration of cosolvan and the time of using breathing machine （P〈0.05）.Conclusion Ambroxol can improve ventilation--air change function of MAS newborns, degrade mean airway pressure,decurtate the time of mechanical ventilation.