| 胰岛素对糖尿病大鼠动脉壁肌球蛋白轻链激酶表达的影响 |
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| 引用本文： | 高峻岭,杜勇,左莉,朱华庆,周青,桂淑玉,汪渊.胰岛素对糖尿病大鼠动脉壁肌球蛋白轻链激酶表达的影响[J].安徽医科大学学报,2011,46(6):519-523. |
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| 作者姓名： | 高峻岭 杜勇 左莉 朱华庆 周青 桂淑玉 汪渊 |
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| 作者单位： | 安徽医科大学分子生物学实验室、生物化学与分子生物学教研室、省部共建教育部重要遗传病基因资源利用重点实验室,合肥,230032;安徽医科大学第一附属医院呼吸内科,合肥,230022 |
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| 基金项目： | 国家自然科学基金，安徽省自然科学基金 |
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| 摘 要： | 目的 探讨胰岛素是否通过细胞外信号调节激酶(ERK)通路调控糖尿病模型大鼠动脉壁肌球蛋白轻链激酶(MLCK)的表达.方法 SD大鼠45只,随机分为正常对照组、高脂对照组、糖尿病组、胰岛素治疗组,通过腹腔注射链尿佐菌素(STZ)复制糖尿病大鼠模型,心脏取血检测血清学指标,采用免疫组化法和Western blot法分析大鼠...
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| 关 键 词： | 糖尿病 糖尿病血管病变 肌球蛋白轻链激酶 细胞外信号调节MAP激酶类 胰岛素 大鼠 |
Effects of insulin on expression of myosin light chain kinase in the artery wall of diabetic rats |
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| Gao Junling,Du Yong,Zuo Li,et al.Effects of insulin on expression of myosin light chain kinase in the artery wall of diabetic rats[J].Acta Universitis Medicinalis Anhui,2011,46(6):519-523. |
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| Authors: | Gao Junling Du Yong Zuo Li |
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| Institution: | Gao Junling,Du Yong,Zuo Li,et al(Laboratory of Molecular Biology,Dept of Biochemistry of Anhui Medical University,Key Laboratory of Gene Resource Utilization for Severe Disease of Anhui Province,Hefei 230032) |
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| Abstract: | Objective To explore the possibility that the expression of myosin light chain kinase(MLCK) in the artery wall of diabetic rats is regulated by the insulin through the pathway of extracellular signal-regulated kinase(ERK).Methods Forty-five SD rats were randomly divided into control group,high-lipid diet group,diabetic group and insulin group.The diabetic rat model was induced by intraperitoneal injection of streptozotocin(STZ).The serum glucose and lipid levels were measured each group.The expression of ML... |
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| Keywords: | diabete mellitus diabetic angiopathies myosin light chain kinase extracellular signal-regulated MAP kinases insulin rats |
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