Survivin与VEGF及其受体FLT-1在结直肠癌中的表达及其临床意义

目的探讨结直肠癌组织中凋亡抑制因子Survivin与血管内皮生长因子(VEGF)及其受体FLT-1表达、相互关系及临床意义。方法采用免疫组织化学SP法检测82例结直肠癌组织和28例癌旁黏膜组织中Survivin与VEGF及其受体FLT-1表达的状况。结果结直肠癌组织中Survivin表达率为67.1%(55/82),VEGF及其受体FLT-1表达率分别为69.5%(57/82)和82.9%(68/82),均明显高于癌旁黏膜组织组(P<0.05)。Survivin表达与结直肠癌的Dukes分期有关(P<0.05)。VEGF表达与结直肠癌淋巴结转移和Dukes分期有关(P<0.05),而受体FLT-1表达与各临床病理因素无关(P>0.05)。在结直肠癌中Survivin表达与VEGF表达呈正相关(r=0.358,P<0.05)。VEGF和FLT-1表达呈正相关(r=0.565,P<0.05)。结论Survivin和VEGF表达在结直肠癌发生过程中起重要作用,检测Sur-vivin和VEGF表达水平有助于反映结直肠癌进展和预后判断。

Expression and clinical significance of Survivin, VEGF and its receptor FLT-1 in colorectal carcinoma

Objective To investigate the expression and clinical significance of Survivin,VEGF and its receptor FLT-1 in colorectal carcinoma.Methods Immunohistochemica1 SP method was used to detect the expression of Survivin,VEGF and its receptor FLT-1 in 82 cases of colorectal carcinoma and 28 cases of paracarcinoma tissue.Results The expression rate of Survivin was 67.1%(55/82) ,VEGF and its receptor FLT-1 were 69.5%(57/82) and 82.9%(68/82)in colorectal carcinoma,and higher than that in paracarcinoma tissue(P<0.05),respectively; Survivin protein significantly related with Duke stage (P<0.05),The expression of VEGF had obviously association with lymph node metastasis and Duke stage in colorectal carcinoma (P<0.05),and no relationship was observed between the expression of receptor FLT-1 and clinicopathological manifestations(P>0.05). The expression of Survivin was associated with that of VEGF in colorectal carcinoma (r=0.358,P<0.05). The expression of VEGF was associated with that of FLT-1 in colorectal carcinoma (r=0.565,P<0.05).Conclusion Abnormal expression of Survivin and VEGF play an important role in carcinogenesis of colorectal carcinoma. The detection of Survivin and VEGF may be useful for evaluating the progress and prognosis of colorecta1 carcinoma.