Peroxiredoxin 1与EMT相关蛋白在胰腺癌组织中的表达及其临床意义 |
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引用本文: | 蔡重阳,汤志刚,黄强,陈炯,潘婷婷,翟路路. Peroxiredoxin 1与EMT相关蛋白在胰腺癌组织中的表达及其临床意义[J]. 安徽医科大学学报, 2015, 0(3): 368-372 |
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作者姓名: | 蔡重阳 汤志刚 黄强 陈炯 潘婷婷 翟路路 |
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作者单位: | 1. 安徽医科大学附属省立医院普通外科,肝胆胰外科安徽省重点实验室,合肥 230001;2. 天津医科大学研究生院,天津,300070 |
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摘 要: | 目的:探讨过氧化物还原酶1( Prx1)与上皮细胞间质转化( EMT)相关蛋白在胰腺癌组织中的表达及其临床意义。方法采用免疫组化法分别检测 Prx1、E-钙黏素( E-cadherin)、波形蛋白( Vimentin)在66例胰腺癌组织和11例正常胰腺组织中的表达,并分析三者之间的关系及与临床病理因素间的关系。结果 Prx1、E-cadherin和Vimentin分别在66例胰腺癌组织中的阳性表达率为69.70%(46/66)、40.91%(27/66)、56.06%(37/66);Prx1、E-cadherin和Vim-entin分别在11例正常胰腺组织中的阳性表达率为18.18%(2/11)、90.90%(10/11)、18.18%(2/11)。 Prx1、E-cadherin和Vimentin在胰腺癌组织中的表达均与TNM分期、淋巴结转移和肿瘤分化程度显著相关(P<0.05),而与性别、年龄、肿瘤大小、病变部位均无关;Prx1与神经侵犯显著相关( P<0.05),而E-cadherin和Vimentin与神经侵犯无关。 Prx1的表达与Vimentin表达呈正相关(P<0.05),Prx1和Vimentin的表达均与 E-cadherin表达呈负相关( P<0.05)。结论Prx1与EMT相关蛋白在胰腺癌组织中的表达呈显著相关性,并与其侵袭转移能力相关,提示Prx1的高表达可能为预测胰腺癌患者预后不良的辅助指标之一。
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关 键 词: | 胰腺癌 过氧化物还原酶1 E-钙黏素 波形蛋白 |
Clinical significance of expression of Peroxiredoxin 1 and EMT related factors in pancreatic carcinoma |
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Affiliation: | Cai Chongyang;Tang Zhigang;Huang Qiang;Dept of General Surgery,The Affiliated Provincal Hospital of Anhui Medical University,Anhui Province Key Laboratory of Hepatopancreatobiliary Surgery; |
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Abstract: | Objective To investigate the expression clinical significance of Peroxiredoxin 1 ( Prx1 ) and epithelial mesenchymal transition (EMT)-related factors in pancreatic carcinoma. Methods The expression of Prx1, E-cad-herind and Vimentin were detected in 66 pancreatic carcinoma samples and 11 normal pancreatic tissues by immu-nohistochemical method. The correlation between Prx1, E-cadherin, Vimentin and clinicopathologic characteristics was also analyzed. Results The positive expression rates of Prx1, E-cadherind and Vimentin were 69. 70% (46/66), 40. 91% (27/66) and 56. 06% (37/66) in pancreatic carcinoma, and 18. 18% (2/11), 90. 90% (10/11) and 18. 18% (2/11) in normal pancreatic tissue, respectively. The expression rates of Prx1, E-cadherin and Vimentin were correlated with TNM stage, lymph node metastasis, degree of differentiation ( P <0. 05 ) . Prx1 expression was correlated with nerve invasion in pancreatic carcinoma tissue ( P<0. 05 ) . The expression rates of Prx1, E-cadherin and Vimentin were not correlated with sex, age, size, site of tumor. E-cadherin and Vimentin expression were not correlated with nerve invasion inpancreatic carcinoma tissue. Prx1 expression in pancreatic car-cinoma was positively correlated with Vimentin expression ( P<0. 05 );Prx1 and Vimentin were negatively correla-ted with E-cadherin expression ( P<0. 05 ) . Conclusion Prx1 , E-cadherin and Vimentin expressions are associ-ated with the ability of invasion and metastasis in pancreatic carcinoma, Prx1 abnormal expression maybe serve as a potential poor prognostic marker of patients with pancreatic carcinoma. |
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Keywords: | pancreatic carcinoma Peroxiredoxin 1 E-cadherind Vimentin |
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