UL16结合蛋白在胰腺癌中的表达及其临床意义

目的 检测UL16结合蛋白(ULBP)在胰腺癌患者中的表达及其临床意义.方法 免疫组化分析ULBP在62例胰腺癌组织和62例癌旁组织的表达,ELISA法检测62例胰腺癌患者外周血中ULBP的表达和35例健康对照者中ULBP和CA19-9的表达.ROC曲线和Logistic回归分析比较ULBP和CA19-9对胰腺癌患者的诊断价值.结果ULBP1和ULBP2在胰腺癌组织中的表达均高于癌旁组织(χ2=7.352,P=0.007;χ2=11.648,P=0.001).s-ULBP2在胰腺癌患者外周血中的含量高于健康对照者;s-ULBP2与CA19-9联合后对胰腺癌的诊断价值高于单独CA19-9.结论 ULBP1 和 ULBP2 在胰腺癌组织中的表达升高且 ULBP1的表达阳性率和胰腺癌组织的临床病理资料有关. ULBP2在胰腺癌患者外周血中的表达量高于健康对照者且ULBP2和CA19-9联合后能够提高CA19-9单独用于胰腺癌的诊断价值.

Expression and clinical significance of UL16 binding proteins in pancreatic carcinoma

Objective To investigate the expression and clinical significance of UL16 binding proteins( ULBP) in pancreatic cancer. Methods Immunohistochemistry was used to detect the expressions of ULBP in tumor tissues and adjacent non-tumor tissues from a total of 62 patients with pancreatic carcinoma. ELISA was used to detect the expression of ULBP in patients with pancreatic cancer and healthy people. Then ROC curve and Logistic regression analysis were taken to analyze the diagnostic value of ULBP, compared with carbohydrate antigen 19-9(CA19-9) . Results The positive expression rates of ULBP1 and ULBP2 were higher in tumor tissues than in adjacent non-tumor tissues(χ2 =7. 352,P =0. 007;χ2 =11. 648,P =0. 001) . The level of ULBP2 in the peripheral blood of pancreatic cancer patients was higher than healthy people. Besides, the diagnostic value of the combination of ULBP2 and CA19-9 was higher than CA19-9 alone. Conclusion Up-regulated ULBP2 is significantly correlated with the clinical TNM stage of pancreatic cancer patients , peri-neural invasion of tumor tissue and the differentiated degree of cancer cells. The combinational diagnosis of ULBP2 and CA19-9 is better than CA19-9 alone.