脑震荡后认知功能障碍患者内侧前额叶皮质功能连接变化的fMRI研究

目的 利用静息态功能磁共振成像探讨脑震荡综合征(PCS)患者内侧前额叶皮质功能连接变化及其意义. 方法 PCS患者27例,同期招募27例健康对照者,采集并处理静息态f-MRI数据,分别以左右侧内侧前额叶作为感兴趣区与全脑进行功能连接计算,得出PCS患者内侧前额叶与全脑功能连接有改变的脑区.结果 左侧内侧前额叶与双侧豆状核、左侧脑岛、双侧额下回眶部、右侧颞中回、额上回、额中回、额下回功能连接减弱,与左侧梭状回、左侧颞上回、左侧颞中回及左侧顶上小叶功能连接增强;右侧内侧前额叶与双侧顶下小叶、右侧距状回、左侧中央前回及中央后回功能连接减弱,与左侧海马旁回及右侧颞下回功能连接增强(P<0.05).结论 静息状态下PCS患者内侧前额叶的功能连接存在异常,可能是导致PCS患者认知障碍的原因之一.

Alteration of medial prefrontal cortex functional connectivity in the roleof cognitive disorder after concussion: a resting-state fMRI study

Objective To study the alteration of the medial prefrontal cortex functional connectivity in post-concussion syndrome(PCS) patients by resting-state functional magnetic resonance imaging(fMRI).Methods The resting-state fMRI data acquired from 27 PCS patients and 27 healthy volunteers.The right and left medial prefrontal cortex were selected as region of interest to make functional connectivity (FC) calculation with the whole brain after the data preprocessing.At last the brain regions with altered functional connectivity with the medial prefrontal cortex were cleared after the study.Results Compared with the health controls, left medial prefrontal cortex in PCS patients showed decreased FC with bilateral lentiform nucleus,left insula, bilateral inferior frontal gyrus orbit, back in the right temporal, superior frontal gyrus, middle frontal gyrus and inferior frontal gyrus et al,on the contrary with the increased FC with the left fusiform gyrus, the left superior temporal, the left middle temporal gyrus and the left superior parietal lobule et al.The right medial prefrontal cortex in PCS patients showed decreased FC with bilateral inferior parietal lobule,right cryptocalcarine gyrus, left cerebral precentral gyrus, and posterior central gyrus et al.Similarly, it had the increased FC with the left parahippocampal gyrus and the right inferior temporal gyrus et al.Conclusion There are medial prefrontal cortex functional connectivity abnormities in PCS patients that may lead to cognitive disorder.