| 105例非小细胞肺癌表皮生长因子受体基因突变分析 |
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| 引用本文： | 张志红,倪琛琛,于敏,杨青,许晓兰,朱莹莹.105例非小细胞肺癌表皮生长因子受体基因突变分析[J].安徽医科大学学报,2011,46(8):740-742. |
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| 作者姓名： | 张志红 倪琛琛 于敏 杨青 许晓兰 朱莹莹 |
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| 作者单位： | 安徽医科大学第一附属医院老年呼吸内科,合肥,230022;安徽医科大学第一附属医院老年呼吸内科,合肥,230022;安徽医科大学第一附属医院老年呼吸内科,合肥,230022;安徽医科大学第一附属医院老年呼吸内科,合肥,230022;安徽医科大学第一附属医院老年呼吸内科,合肥,230022;安徽医科大学第一附属医院老年呼吸内科,合肥,230022 |
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| 基金项目： | 安徽医科大学中青年学术骨干 |
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| 摘 要： | 目的 分析表皮生长因子受体(EGFR)在非小细胞肺癌(NSCLC)中的基因突变率及突变类型.方法 收集105例肺癌组织和80例正常肺组织,采用PCR扩增和基因测序方法,对组织DNA中EGFR外显子19和21进行基因突变分析.结果 非小细胞肺癌组织中EGFR基因突变率为33.33%(35/105),其中外显子19占42....
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| 关 键 词： | 癌 非小细胞肺 表皮生长因子受体 突变 |
Gene mutational analysis of EGFR in 105 cases of non-small cell lung cancer |
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| Zhang Zhihong,Ni Chenchen,Yu Min,et al.Gene mutational analysis of EGFR in 105 cases of non-small cell lung cancer[J].Acta Universitis Medicinalis Anhui,2011,46(8):740-742. |
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| Authors: | Zhang Zhihong Ni Chenchen Yu Min |
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| Institution: | Zhang Zhihong,Ni Chenchen,Yu Min,et al(Dept of Geriatric Pulmonology,The First Affiliated Hospital of Anhui Medical University,Hefei 230022) |
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| Abstract: | Objective To analyze the incidence and types of mutations in epidermal growth factor receptor(EGFR) in patients with non-small cell lung cancer(NSCLC).Methods 105 cases of NSCLC tissue and 80 cases of normal lung samples were measured in this study.The way of PCR amplification and gene sequencing were used to analyze the mutation of EGFR in exon 19 and 21.Results 35 cases of mutations were found in 105 lung cancer samples,with an incidence of 33.33%.There were 42.86% mutation in exon 19 and 57.14% mutation ... |
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| Keywords: | carcinoma non-small cell lung receptor epidermal growth factor mutation |
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