| 氧化还原状态与细胞信号传导 |
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| 引用本文： | 刘漪沦,孙静,刘月明.氧化还原状态与细胞信号传导[J].成都医学院学报,2009,4(2):127-131. |
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| 作者姓名： | 刘漪沦 孙静 刘月明 |
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| 作者单位： | 1. 成都医学院第一附属医院烧伤整形科,成都,610500
2. 成都医学院病理学教研室,成都,610083 |
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| 基金项目： | 国家自然科学基金面上项目 |
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| 摘 要： | 细胞内氧化还原状态的变化决定着氧化还原反应的发生方向，并通过一定的机制进行制衡。细胞膜以及细胞内分子的氧化或还原反应，导致发生结构或构象的改变，在细胞的信号转导、基因转录等过程中发挥重要的调控功能，对细胞生命活动产生着重要的影响。酪氨酸蛋白激酶与磷酸酶、丝苏氨酸激酶与磷酸酶、磷脂酶及其代谢产物、钙离子等重要信号分子可通过氧化还原反应介导细胞信号的传导。细胞内这种氧化还原信号传导体系受到复杂而灵敏的调控。目前在分子水平上进一步认识氧化还原状态对细胞调控的机制具有重要的意义。
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| 关 键 词： | 氧化还原状态 细胞 信号传导 |
Relationship Between Redox State and Cellular Signal Transduction |
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| Authors: | LIU Yi-lun SUN Jing LIU Yue-ming |
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| Institution: | LIU Yi-lun , SUN Jing , LIU Yue-ming (1. Department of Burn ＆ Plastic Surgery, First Affiliated Hospital of Chengdu Medical College, Chengdu 610500, China ; 2. Department of Pathology, Chengdu Medical College, Chengdu 610083, China ) |
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| Abstract: | The diection of cellular redox reaction was determined by redox state. Signal transduction,genetic transciption could be regulated by the change of cellular molecular structure through redox reaction.. Signal transduction could be mediated by redox reaction through protein tyrosine kinase/phosphatase, protein-serine-threonine kinases / phosphatase,phosholipase, calcium ion and other significant signaling molecules. The regulation of redox- signal transduction system was sensitive and complicated. It was important to realize the regulation mechanism of redox state on cellular molecular level. |
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| Keywords: | redox state cell signal transduction |
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