加味六君子汤对肺癌术后化疗免疫功能的影响

目的 观察加味六君子汤对肺癌术后化疗免疫功能的影响,并分析其意义.方法 选取2014年6月至2016年12月西南医科大学附属中医医院和四川省彭州市中医医院肺癌术后患者共90例,随机分为试验组(n=47)和对照组(n=43);其中,试验组采用化疗联合加味六君子汤治疗,对照组单用化疗.3周后,观察两组治疗前后细胞免疫、体液免疫、外周血淋巴细胞百分率和绝对值计数变化,并且监测血常规、肝肾功能、心电图以及异常症状等.结果 试验组CD3、CD4、CD4/CD8 、CD56较治疗前升高(P<0.05),而CD8治疗前后比较差异无统计学意义(P>0.05);IgG较治疗前升高,差异有统计学意义(P<0.05),而IgA、IgM与治疗前比较,差异无统计学意义(P>0.05);淋巴细胞百分率和淋巴细胞绝对值计数较治疗前升高,差异有统计学意义(P<0.05).对照组CD3、CD4、CD4/CD8、CD8、CD56 与治疗前比较,差异无统计学意义(P>0.05);IgG、IgA、IgM 与治疗前比较,差异无统计学意义(P>0.05);淋巴细胞百分率和淋巴细胞绝对值计数与治疗前比较,差异无统计学意义(P>0.05).两组患者治疗过程中均有不良反应发生,但试验组出现例次较对照组明显减少.结论 加味六君子汤能够改善肺癌术后化疗的免疫抑制反应,并且减少不良反应的发生,可应用于癌症术后化疗的辅助治疗.

The Effect of Modified Liujunzi Decoction on the Immune Function of Patients with Lung Cancer in the Postoperative Chemotherapy

Objective To investigate the effect of Modified Liujunzi Decoction on the immune function of patients with lung cancer in the postoperative chemotherapy and analyze its significance.Methods 90 cases with lung cancer treated in Affiliated Traditional Chinese Medicine Hospital of Southwest Medical University and Pengzhou Hospital of Traditional Chinese Medicine from June of 2014 to December of 2016 were selected and divided into the experiment group (n=47) and the control group (n=43).The experiment group was given the chemotherapy combined with Modified Liujunzi Decoction, while the control group was treated with the chemotherapy.The changes of cellular immunity, humoral immunity, and the percentage and absolute count of lymphocytes in the two groups were detected before treatment and after 3 weeks of treatment.The other indexes including the blood routine, function of liver and kidney, electrocardiogram and abnormal symptoms were also observed.Results CD3, CD4, CD4/CD8, CD56 in the experiment were significantly higher after treatment than before treatment (P<0.05), while there was no significant difference in CD8 between before and after treatment (P>0.05).IgG in the experiment was significantly higher after treatment than before treatment (P<0.05), while there were no significant differences in IgA and IgM between before and after treatment (P>0.05).The percentage and absolute count of lymphocyte in the experiment rose after treatment, and the differences were statistically different (P<0.05).There were no significant differences in the indexes including CD3, CD4, CD4/CD8, CD8, CD56, IgG, IgA, IgM, and the percentage and absolute count of lymphocyte in the control group between before and after treatment (P>0.05).There were adverse reactions in both groups, while there were less in the experiment group than in the control group.Conclusion Modified Liujunzi Decoction can improve immunosuppression of patients with lung cancer in the postoperative chemotherapy and reduce the adverse reactions, so it can be applied clinically as an adjuvant treatment of postoperative chemotherapy.