中药全蝎抗肿瘤作用初探——Ⅰ.对带瘤小鼠的作用观察

为探索中药全蝎抗肿瘤作用,我们用全蝎提取液和粗提物,观察其对网状细胞肉瘤(SRS)和MA—737乳腺癌带瘤小鼠肿瘤生长过程的作用。结果:当以全蝎提取液0.2ml,相当生药0.04g/只,隔天皮下给药连用5次后,在用药第11天和停药第8天时,对SRS实体瘤的抑制率为38.8％(P<0.05)和55.5％(P<0.01);对MA—737乳腺癌,每天用药,计12次后抑制率为51.8％(P<0.01),停药8天时为30.4％(P<0.05)。全蝎提取液对SRS腹水型带瘤小鼠的生存率较对照组延长12.5％～20.7％(P<0.01)。全蝎提取液对肿瘤细胞化学的影响,可使上述两种瘤组织的DNA明显减少;并使乳腺癌逐渐增多的AKP趋向减少。表明全蝎对带瘤小鼠的肿瘤生长有明显抑制作用。

A PRELIMINARY RESEARCH OF THE ANTINEOPLASIA EFFECTS INDUCED BY BUTHUS MARTENSII OF CHINESE DRUG—Ⅰ. OBSERVATION OF THE EFFECT ON MICE WITH TUMOR

An investigation of antineoplasia effect induced by Buthus martensii (BM) of Chinese drug in mice with SRS or MA—737 mammary carcinoma has been made and is reported here. The extract solution or material of BM was given subcutaneously in the dose of 0.2ml(=crude drug 0.04g)/mouse,every other day, for five times. The inhibitory rate on SRS soild tumor was 38.8％ (P<0.05) and 55.5％ (P<0.01) on the 11th day during drug administration and the 8th day after administration, respectively. The inhibitory rate on MA—737 mammary carcinoma was 51.8％ (P<0.01) on the 12th day during drug administration every day and 30.4％ (P<0.05) on the 8th day after administration. The existence rate of SRS ascites type mice with tumor in the BM administering group was 12.5—20.7％ (P<0.01) longer than that in the contrast group. The cytochemistry of tumor was also affected by the extract solution of BM: DNA in the tissues of both tumors was obviously diminished and the gradually increased AKP in mammary carcinoma was decreased tendentiously. Apparently, Buthus martensii has an obvious inhibiting effect on neoplasm growth in mice with tumor.