辛伐他汀对自发性高血压大鼠左室舒张功能的影响

目的　观察辛伐他汀对自发性高血压大鼠 (SHR)左室舒张功能的影响。方法　采用Bergman法和心导管技术 ,测定大鼠用药 2mg/ (kg·d) ,连续 12周灌胃 ]后的心肌胶原含量和左室舒张功能。 结果　辛伐他汀治疗组能明显降低SHR心肌胶原含量 ,改善左室舒张功能 (P <0 .0 5 ,P <0 .0 1)。对血压、心率虽有所降低 ,但无统计学意义 (P >0 .0 5 )。结论　辛伐他汀能在一定程度上改善SHR左室舒张功能和心肌纤维化。

Effect of simvastatin on left ventricular diastolic function in spontaneously hypertensive rats

ObjectiveTo investigate effects of simvastatin on left ventricular diastolic dysfunction in spontaneously hypertensive rats (SHR) MethodsSixteen male SHRs of 16-week-old were divided into two groups at random: SHR-C group (2ml distilled water,n=8) and SHR-S group simvastatin,2 mg/(kg·d),n=8],SHR-C group was administered for 12 weeks with intragastric simvastatin,SHR -C group and 8 sex-age matched Wistar Kyoto rats(WKY)were given the distilled water only.Systolic blood pressure(SBP) and heart rate were measured by tail-cuff method; collagen concentration were determined by modified Bergman method.Left ventricular diastolic function was measured by cardiac catheterization technique.ResultsAfter 12 weeks treatment,compared with SHR-C group,collagen concentration ? left ventricular end-diastolic pressure were reduced significantly and -dp/dt\-\{max\} reduced significantly (P<0.05 or P<0.01),but +dp/dt\-\{max\} ?SBP and heart rate were no significant alteration for SHR-S group (P>0.05).ConclusionSimvastatin can improve left ventricular diastolic function and reduce myocardial fibrosis in spontaneously hypertensive rats