注射用白眉蛇毒血凝酶在妇科手术中的应用研究

目的探究注射用白眉蛇毒凝血酶在妇科手术中的应用疗效。方法选取本院2017年6月至2020年6月收治的50例行妇科手术的患者,按照随机数表法分为实验组与参照组,各25例。实验组术前给予注射用白眉蛇毒血凝酶2 U静脉注射,参照组给予等计量0.9%氯化钠溶液,比较两组出血时间、单位面积出血量、血红蛋白、活化部分凝血活酶时间、凝血酶原时间、凝血酶时间及空腹血糖指标。结果实验组出血时间短于参照组,单位面积出血量少于参照组,血红蛋白高于参照组,作用总有效率(96.00%)明显高于参照组(72.00%),差异有统计学意义(P<0.05);术后,实验组活化部分凝血活酶时间、凝血酶原时间、凝血酶时间及空腹血糖与术前比较差异无统计学意义。结论注射用白眉蛇毒血凝酶应用于妇科手术可减少单位面积出血量和出血时间,凝血状态差异较小,无不良反应,值得临床推广应用。

Study on the application of hemagglutinin from the snake venom for injection in gynecological surgery

Objective To explore the curative effect of hemagglutinin from the snake venom for injection in gynecological surgery. Methods 50 patients undergoing gynecological surgery admitted to our hospital from June 2017 to June 2020 were selected, and they were divided into the experimental group and the reference group according to the random number table method, with 25 cases in each group. Before the operation, the patients in the experimental group were given 2U intravenous injection of hemagglutinin from the snake venom for injection, and the patients in the reference group were given equivalent amount of 0.9% sodium chloride solution. The bleeding time, bleeding volume per unit area, hemoglobin, activated partial thromboplastin time, prothrombin time, thrombin time and fasting blood glucose indicators were compared between two groups. Results The bleeding time in the experimental group was shorter than the reference group, and the amount of bleeding per unit area of gynecological surgery in the experimental group was less than the reference group, and hemoglobin was higher than the reference group. The total effective rate(96.00%) of the experimental group was significantly higher than that of the reference group(72.00%), the difference was statistically significant(P<0.05). After the operation, there was no significant difference in the activated partial thromboplastin time, prothrombin time, thrombin time and fasting blood glucose of the experimental group compared with preoperatively. Conclusion The application of hemagglutinin from the snake venom for injection in gynecological surgery can reduce the amount of bleeding per unit area and the bleeding time, the coagulation status is small, and there is no adverse reaction.It is worthy of clinical application and promotion.