首页 | 本学科首页   官方微博 | 高级检索  
检索        

牛S抗原的提取、鉴定及EAU模型的建立
引用本文:郭涛,张凤蕴,王丽群,高淑英,崔洪波,李迪,王红,李殿俊.牛S抗原的提取、鉴定及EAU模型的建立[J].哈尔滨医科大学学报,2002,36(2):100-101,F004.
作者姓名:郭涛  张凤蕴  王丽群  高淑英  崔洪波  李迪  王红  李殿俊
作者单位:1. 哈尔滨医科大学,免疫学教研室,黑龙江,哈尔滨,150086
2. 哈尔滨医科大学,微生物学教研室,黑龙江,哈尔滨,150086
基金项目:黑龙江省自然科学基金资助项目 (D 2 0 0 1)
摘    要:目的 建立实验性自身免疫性葡萄膜炎(EAU)动物模型,研究自身免疫病的发病机制。方法 依据AI-Mahdawi等的方法并加以改进,自牛视网膜组织提取S抗原,并用免疫Wistar大鼠。结果 提取的S抗原与文献报告结果大致相同,免疫的Wistar大鼠全部出现典型的EAU病变,观察临床症状及病理检测。结论 以牛S抗原免疫Wistar大鼠的EAU模型建立成功。

关 键 词:  S抗原  提取  鉴定  EAU模型  葡萄膜视网膜炎  自身免疫病  小鼠
文章编号:1000-1905(2002)02-0100-02

Purification and identification of S-antigen in bovine retina and construction of EAU model
GUO Tao,ZHANG Feng yun,WANG Li qun,et al.Purification and identification of S-antigen in bovine retina and construction of EAU model[J].Journal of Harbin Medical University,2002,36(2):100-101,F004.
Authors:GUO Tao  ZHANG Feng yun  WANG Li qun  
Abstract:Objective To study the immunological mechanism of experimental autoimmune uveoretinitis(EAU).Methods Adopted the improved AI Mahdani's method to purify bovine retinal S Ag and then used it to immune Wistar mice.The clinical symptoms were observed and the pathological changes were investigated. Results The purified S Ag was almost the same as it reported in the other research references, which successfully induced the EAU of Wistar mice. Conclusion The EAU model is successfully induced in Wistar mice immuned with bovine retinal S Ag.
Keywords:uveoretinitis  S  antigen  autoimmune disease  mouse
本文献已被 CNKI 维普 万方数据 等数据库收录!
设为首页 | 免责声明 | 关于勤云 | 加入收藏

Copyright©北京勤云科技发展有限公司  京ICP备09084417号