| 纳洛酮对脑缺血大鼠皮层SEP和Ca2+-ATP酶活性的影响 |
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| 引用本文： | 曲丽辉,李玉荣,贾淑伟,田淑君,祖英秋,张颖,邹向晖.纳洛酮对脑缺血大鼠皮层SEP和Ca2+-ATP酶活性的影响[J].哈尔滨医科大学学报,2004,38(1):45-47. |
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| 作者姓名： | 曲丽辉 李玉荣 贾淑伟 田淑君 祖英秋 张颖 邹向晖 |
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| 作者单位： | 哈尔滨医科大学,生理学教研室,黑龙江,哈尔滨,150086 |
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| 摘 要： | 目的研究纳洛酮对脑缺血大鼠皮层体感诱发电位(SEP)和Ca2+-ATP酶活性的影响,探讨纳洛酮对急性脑缺血损伤的脑保护作用机制.方法在大鼠大脑中动脉栓塞动物模型基础上,侧脑室注射不同剂量纳洛酮,以皮层SEP和Ca2+-ATP酶活性为指标,观察纳洛酮对脑缺血的作用.结果脑缺血后,皮层SEP主波消失,Ca2+-ATP酶活性显著降低(P<0.001),纳洛酮可在一定程度上恢复SEP(P<0.01),并使Ca2+-ATP酶活性升高(P<0.01).结论纳洛酮对大鼠急性脑缺血损伤有一定的保护作用.
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| 关 键 词： | 脑缺血 药物治疗 纳洛酮 皮层体感诱发电位 Ca^2＋-ATP酶 |
| 文章编号： | 1000-1905(2004)01-0045-03 |
| 修稿时间： | 2003年7月31日 |
Effect of naloxone on SEP and Ca2+-ATPase activity in cerebral ischemia rats |
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| QU Li hui,LI Yu rong,JIA Shu wei,et al.Effect of naloxone on SEP and Ca2+-ATPase activity in cerebral ischemia rats[J].Journal of Harbin Medical University,2004,38(1):45-47. |
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| Authors: | QU Li hui LI Yu rong JIA Shu wei |
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| Abstract: | Objective To study the effect of naloxone on the somatosensory evoked potential (SEP) and Ca 2+ ATPase activity in cerebral ischemia rats.Methods The intracerebroventrical(icv) administration of naloxone was used in the middle cerebral artery occlusion (MCAO) model in Wistar rats and the change of SEP and Ca 2+ ATPase activity were observed.Results The primary waves were disappeared and Ca 2+ ATPase activity was decreased ( P < 0.001 ) in cerebral ischemia rats.Naloxone could enhance the amplitude of SEP ( P < 0.01 ) and Ca 2+ ATPase activity ( P <0.05).Conclusion Naloxone have the protective effect on cerebral ischemia rats. |
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| Keywords: | naloxone cerebral ischemia SEP Ca 2+ ATPase activity rat |
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