单纯性肥胖青少年体脂分布与血压及胰岛素抵抗

目的 探讨单纯性肥胖青少年体脂分布与血压及纱抵抗之间的关系。方法 测定了２７例单纯性肥胖青少年及１０例非肥胖健康人空腹及口服７５ｇ糖后１ｈ、２ｈ的血糖及胰岛素浓度，计算胰岛素敏感指数（ＩＳＩ，ＲＩＳＩ），比较各指标间的相关性。结果 肥胖患者基础及县７５ｇ糖后１ｈ、、ｈｙ胰岛素值均６高于对照组（Ｐ〈０．００１），胰岛素敏感指数（ＩＳＩ，ＲＩＳＩ）低

The relationship of fatty distribution, blood pressure and insulin resistance in adolescent obesity

Objective To investigate the relationship of fatty distribution, blood pressure and insulin resistance in adolescent obesity.Methods The levels of serum insulin and glucose were measured in fasting state and 1-,2-hour after 75g glucose load in 27 subjects with adolescent obesity and 10 no-obese healthy subjects. Insulin sensitivity index (ISI)and relative insulin sensitivity index (RISI) were calculated.Results The serum insulin levels of fasting state 1-,2-hour after 75g glucose load were significantly greater in the obese adolescents than those in the control ( P <0.001).ISI and RISI in the group of obese adolescents were lower than those in the controls( P <0.001).Comparing with the peripheral obese subjects,the ISI in the central obese group was much lower.Conclusion Obese adolescents are susceptible to hyperinsulinemia, insulin resistance and hypertension,which is much more obvious in central obese subjects. ISI is better than RISI in reflecting insulin sensitivity.