隆突性皮肤纤维肉瘤组织学分型及免疫组织化学研究

目的 探讨隆突性皮肤纤维肉瘤的组织学分型及免疫组织化学表达的关系。方法 采用HE染色和免疫组化S－P法对42例隆突性皮肤纤维肉瘤作临床病理分析。结果 42例肿瘤可分为经典型、纤维肉瘤变型、粘液型和色素型。各亚型中CD34均阳性表达；Vimentin表达较弱，有时不稳定；nm23、Ki-67、p53在各亚型间表达的差异无统计学意义。结论 经典型隆突性皮肤纤维肉瘤是一种低度恶性肿瘤，纤维肉瘤变型的恶性率较高，粘液型和色素型的恶性度与其它两型的差异有待于进一步观察。CD34稳定阳性表达对隆突性皮肤纤维肉瘤的诊断及鉴别诊断有一定意义。

Study on histological classification and immunohistochemical expression in dermatofibrosarcoma protuberans

Objective To investigate the relationship between histological classification and immunohistochemical expression in dermatofibrosarcoma protuberans(DFSP). Methods 42 DFSP cases were analysed by clinical pathology with HE stain and S P immunohistochemistry.Results 42 cases were classified into conventional, fibrosarcoma lesion, myxoid and melanin pigmented DFSP. CD34 was stablely positive in each subtype DFSP while Vimentin was weak positive, and sometimes unstable; nm23, Ki 67, p53 expression had no statistical difference among the subtype. Conclusion Conventional DFSP is a low grade malignant neoplasm while fibrosarcoma lesion DFSP is more malignant; myxoid and melanin pigmented DFSP would be further to investigate. CD34 is positive and very characteristic for diagnosis and identification of DFSP.