| 亚硝基脲类和亚硝基硫脲类的理化性质及致突变能力 |
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| 引用本文： | 刘凤芝,二宫真一,川添丰.亚硝基脲类和亚硝基硫脲类的理化性质及致突变能力[J].哈尔滨医科大学学报,1988(5). |
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| 作者姓名： | 刘凤芝 二宫真一 川添丰 |
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| 作者单位： | 哈尔滨医科大学肿瘤研究所
(刘凤芝)，日本名古屋市立大学
(二宫真一)，日本名古屋市立大学(川添丰) |
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| 摘 要： | 本题选择N,N′-二甲基亚硝基脲(DMNU),N,N′-二乙基亚硝基脲(DENU),及其类似物N,N′-二甲基亚硝基硫脲(DMNTU)、N,N′-二乙基亚硝基硫脲(DENTU)为代表,测定了这些化合物的水解反应速度、脂溶性(HPLC的logk′值)、水解产物和致突变能力。证明了硫脲的脂溶性大于脲的脂溶性。DMNTU对TA100菌株的致突变能力最强,其它较弱。
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| 关 键 词： | 亚硝基脲 亚硝基硫脲 致突变 |
Physical and Chemical Properties and Mutagenicity of Nitrosoureas and Nitrosothioureas |
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| Liu Fengzhi et al.Physical and Chemical Properties and Mutagenicity of Nitrosoureas and Nitrosothioureas[J].Journal of Harbin Medical University,1988(5). |
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| Authors: | Liu Fengzhi |
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| Institution: | Institute of Oncology |
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| Abstract: | N, N'-Dimethyl-N-nitrosourea, N, N'-diethyl-N-nitrosourea, N, N'-dimethyl-Nnitrosothiourea and N, N'-diethyl-N-nitrosothioureas are the analogues of nitrosoureas. Their rate of hydrolytic reaction and partition properties(logk'on HPLC) were determined. Mutagenicity were tested on TA100 and TA98. Dimethylnitrothiourea were more lipophilic and more toxic to TA100 than dimethylnitrosourea. The other compounds had less activity. |
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| Keywords: | DMNU DMNTU Mutagenicity |
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