内皮素-1和Ki-67在膀胱癌中的表达及意义

目的探讨内皮素-1（ET-1）在膀胱癌中的表达及其与肿瘤细胞增殖的关系。方法应用免疫组化方法对63例膀胱癌中ET-1和Ki-67的表达进行检测。结果63例膀胱癌中ET-1的阳性表达率为30．16％（19／63），明显高于正常组（P〈0．05）。ET-1的表达随着肿瘤的分级增高而增强，各级各期之间ET-1的表达差异均有显著性（P〈0．05）。膀胱癌中Ki-67的表达阳性率为33．33％（21／63），肿瘤分级愈高Ki-67的表达愈强，各组间差异有显著性（P〈0．05），未发现分期间Ki-67的表达差异（P〉0．05）。膀胱癌细胞中ET-1表达和Ki-67表达呈正相关（r=0．623，P〈0．01）。结论ET-1的表达随肿瘤恶性程度的增加而增强，且与Ki-67有明显相关性，提示ET-1的高表达在膀胱癌的发生或发展方面可能起重要作用。

Significance of endothelin-1 and Ki-67 expression in bladder transitional cell carcinoma

Objective To investigate the expression of endothelin-l(ET-l) in bladder neoplasm and the relationship between ET-1 and cell proliferation. Methods Immunohistochemistry was applied to detect ET-1 and Ki-67 expression in 63 patients with transitional cell carcinoma of bladder. Results ET-1 expression in bladder carcinoma was 30.16%, and it was much higher than that in normal bladder samples. ET-1 expression was correlated with the grade and stage of bladder carcinoma(P < 0.05). Of 63 patients, Ki-67 expression was 33.33%, and it increased as grade progress(P < 0.05). ET-1 expression was positively correlated with Ki-67(r = 0.623, P < 0.01). Conclusion ET-1 may play an important role in cell proliferation of bladder carcinoma.