还原型谷胱甘肽对体外循环期细胞因子IL-8和IL-6的影响

目的观察还原型谷胱甘肽对体外循环(CPB)期间白细胞介素-8(IL-8)和白细胞介素-6(IL-6)的影响。方法选择30例施行心脏手术患者,随机分成实验组和对照组(每组15例)。实验组患者于手术开始时分别予还原型谷胱甘肽(35 mg/kg)溶于100 ml生理盐水静滴,对照组予生理盐水静滴。于CPB前(T1)、CPB 30 min(T2)、CPB停机(T3)、停机后2 h(T4)四个时点采血,采用放射免疫法测定两组血清中IL-8和IL-6的浓度。结果实验组IL-8、IL-6血清浓度较对照组降低,差异有统计学意义(P<0.05)。结论还原型谷胱甘肽能减少CPB期间IL-8和IL-6的释放,减轻全身炎性反应的程度。

The effects of GSH on Cytokines IL-8,IL-6 during cardiopulmonary bypass

Objective To investigate the effects of glutathione(GSH) on interleukin-8(IL-8) and interleukin-6(IL-6) during cardiopulmonary bypass(CPB).Methods Thirty patients undergoing Cardiac surgery were randomly divided into GSH group and control group(15 in each group).In GSH group,intravenous drip of 100 ml of GSH(35 mg/kg)was given at the beginning of surgery.Respectively,while the control group was given 0.9% NaCl solution.Blood samples were taken before CPB,30min after CPB and 0h,2h after the end of CPB.The serum levels of IL-8 and IL-6 were measured by radioimmunoassay method in both groups.Results The serum levels of IL-8 and IL-6 in GSH group were significantly lower than that in control group(P<0.05).Conclusion The study shows that GSH could reduce the release of IL-8,IL-6 and inhibit systemic inflammatory response syndrome(SIRS) during CPB.