盐酸氨溴索气管内滴入灌洗佐治新生儿胎粪吸入综合征临床疗效

目的观察盐酸氨溴索气管内滴入灌洗佐治新生儿胎粪吸入综合征(meconium aspiration syndrome,MAS)的临床效果。方法将入选的70例MAS患儿随机分为两组,对照组33例予常规综合疗法并采取支持性护理措施,观察组37例在此基础上加用盐酸氨溴索气管内滴入灌洗,每日1次,持续3d,观察治疗期间两组患儿血氧饱和度(SpO2)、机械通气时间等相关指标与临床疗效。结果治疗48h后,两组患儿SpO2均明显上升,且观察组患儿SpO2明显高于对照组(P<0.05),逐步接近正常值水平;观察组患儿治疗过程中吸痰次数显著少于对照组(P<0.01),机械辅助通气时间及住院时间均显著短于对照组(P<0.01)。治疗5d后,两组患儿症状均改善,观察组的总有效率显著高于对照组(P<0.05)。结论盐酸氨溴索气管内滴入灌洗佐治MAS能提高常规疗法的治疗效果。

Clinical efficacy of ambroxol hydrochloride flushing via intratracheal instillation in assisted treatment of neonatal meconium aspiration syndrome

Objective To observe the clinical efficacy of ambroxol hydrochloride flushing via intratracheal instillation in assisted treatment of neonatal meconium aspiration syndrome(MAS).Methods Relevant indicators including SpO2,assisted ventilation time and the clinical effects of both groups were observed and compared.Results After treating for 48 hours,the SpO2 of both groups obviously increased.And the babies in the observation group had significantly higher SpO2(P<0.05)which gradually got close to the normal level.The frequency of sputum suction of the observation group was obviously less than that of the control group during the treatment(P<0.01).The assisted ventilation time and duration of hospitalization of the observation group were also shorter than those of the control group(P<0.05).After treating for 5 days,symptoms of both groups improved.The total effective rate of the observation group was significantly higher than that of the control group(P<0.05).Conclusion Ambroxol hydrochloride flushing via intratracheal instillation in assisted treatment of MAS can improve the therapeutic effect of conventional treatment.