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糖尿病视网膜病变患者血清CAMS和脂联素水平的分析
引用本文:万惠,姚伟峰,钱铁镛.糖尿病视网膜病变患者血清CAMS和脂联素水平的分析[J].右江医学,2007,35(6):629-631.
作者姓名:万惠  姚伟峰  钱铁镛
作者单位:江苏省无锡市第二人民医院内分泌科,江苏无锡,214000
摘    要:目的分析糖尿病视网膜病变患者的血清细胞黏附分子(CAMS)和脂联素水平及相关性。方法采用放免法测定受试者血清脂联素水平,采用ELISA法检测血清sICAM-1和sVCAM-1水平,同时测定体重指数(BMI)、血脂等指标。结果糖尿病视网膜病变组(DR)血清脂联素水平较DM组和NC组显著降低(P<0.05或<0.01);DR组血清sICAM-1、sVCAM-1水平高于DM组和NC组(P<0.05或<0.01);血清脂联素水平与血清sICAM-1、sVCAM-1水平呈显著负相关(P均<0.01)。结论血清sICAM-1s、VCAM-1以及脂联素参与了糖尿病视网膜病变的发生发展,脂联素可能通过抑制血sICAM-1、sVCAM-1水平对DR起保护作用。

关 键 词:糖尿病视网膜病变  细胞黏附分子  脂联素
文章编号:1003-1383(2007)06-0629-03
收稿时间:2007-08-02
修稿时间:2007-11-06

Serum cellular adhesion molecules level and adiponectin level in patients with diabetic retinopathy
WAN Hui,YAO Wei-feng,QIAN Tie-yong.Serum cellular adhesion molecules level and adiponectin level in patients with diabetic retinopathy[J].Youjiang Medical Journal,2007,35(6):629-631.
Authors:WAN Hui  YAO Wei-feng  QIAN Tie-yong
Abstract:Objective To explore the corelation of serum cellular adhesion molecules and serum adiponectin level in patients with diabetic retinopathy.Methods To detect serum adiponectin with radioimmunoassay,serum sICAM1 and sVCAM-1 with enzyme-linked immunoassay(ELISA).Some other index such as body mass index(BMI),serum lipid were detected too.Results The level of serum adiponectin in diabetic retinopathy group(DR) was significantly lower than that in DM group and NC group(P<0.05and P<0.01);the levels of serum sICAM-1 and sVCAM-1 in DR group were significantly higher than those of DM group and NC group(P<0.05 and P<0.01);The level of serum adiponectin was negatively correlated with the levels of serum sICAM-1 and sVCAM-1(P<0.01).Conclusion Serum sICAM-1、sVCAM-1 and adiponectin may participate in the onset and development of diabetic retinopathy,the adiponectin may protect DR by inhibiting the serum sICAM-1、sVCAM-1.
Keywords:diabetic retinopathy  cell adhesion molecule  adiponectin
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