|
|||||
|
|
| 实验性ICH血肿周围组织IL-8、ICAM-1的动态变化 | |
| 引用本文： | 柯进芳,李政军,赵素琴,杜秦川,张海宇,秦毅.实验性ICH血肿周围组织IL-8、ICAM-1的动态变化[J].宁夏医学杂志,2012,34(6):483-485. |
| 作者姓名： | 柯进芳 李政军 赵素琴 杜秦川 张海宇 秦毅 |
| 作者单位： | 1. 宁夏自治区人民医院急诊科,宁夏银川,750021 2. 宁夏银川市第一人民医院神经内科,宁夏银川,750001 3. 宁夏自治区人民医院放射科,宁夏银川,750021 4. 宁夏医科大学解剖教研室,宁夏银川,750004 |
| 基金项目： | 宁夏自然科学基金资助项目，宁夏自治区卫生厅重点科研项目 |
| 摘 要： | 目的动态观察实验性脑出血(ICH)血肿周围组织白细胞介素8(IL-8)、细胞间黏附分子(ICAM-1)的变化及意义。方法将60只SD大鼠随机分为2组,每组又分为5个时间点。采用肝素化VII型胶原酶脑内注入法制做大鼠ICH模型,应用免疫组化技术监测大鼠ICH后血肿周围组织中IL-8、ICAM-1的动态变化。结果假手术组大鼠针道周围组织各个时间点仅见少量IL-8、ICAM-1表达。模型组各个时间点IL-8、ICAM-1表达均增加,与假手术组比较差异有统计学意义(P<0.05)。结论 ICH后大鼠血肿周围组织IL-8、ICAM-1表达均上调,IL-8,ICAM-1参与了ICH的病理过程。观察IL-8、ICAM-1浓度,对判断病情有一定的帮助。 |
| 关 键 词： | 脑出血 白细偶然性介素8 细胞间黏附分子 |
Dynamic changes of IL-8 and ICAM-1 in brain of intracerebral hemorrhage in rats |
|
| Institution: | KE Jin-fang,et al.Emergency Department,Ningxia People’s Hospital,Yinchuan 750021,China |
| Abstract: | Objective To observe the dynamic changes of IL-8 and ICAM-1 in brain of intracerebral hemorrhage in rats.Methods 60 Sprague-Dawley rats were divided into two groups and each group was divided into five time points.Collagenase type Ⅶ with heparinize was infused into the right caudate nucleus to build up rat experimental ICH model.The IL-8 and ICAM-1 were examined by immunohistochemistry technique.Results A low level of IL-8 and ICAM-1 expression in brain started increased after modeling in every point in sham operation group.The IL-8 and ICAM-1 expression increased after intracerebral hemorrhage in model group.Conclusion IL-8 and ICAM-1 may participate pathology process of the brain after ICH.It is helpful for predicting the state of an illness by observing the density of IL-8 and ICAM-1. |
| Keywords: | Intracerebral hemorrhage Interleukin-8 Intercellular adhesion molecule-1 |
| 本文献已被 CNKI 万方数据 等数据库收录！ | |