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| 芫花根总黄酮的镇痛作用及其机制研究 | |
| 引用本文： | 王莉,郑维发,王建华,崔桂友,夏艳秋.芫花根总黄酮的镇痛作用及其机制研究[J].宁夏医学杂志,2005,27(1):21-23. |
| 作者姓名： | 王莉 郑维发 王建华 崔桂友 夏艳秋 |
| 作者单位： | 1. 安徽建筑工业学院环境工程系,安徽,合肥,230022 2. 徐州师范大学,江苏,徐州,221116 3. 江苏盐城明达学院,江苏,盐城,224300 4. 扬州大学旅游烹饪学院,江苏,扬州,225001 5. 淮海工学院,江苏,连云港,222005 |
| 基金项目： | 研究生课题，江苏省教育厅自然科学基金重点项目(0 2KJA360 0 0 2 ) |
| 摘 要： | 目的观察芫花根总黄酮的镇痛效果，并探讨其镇痛的作用机制。方法采用佐剂性关节炎大鼠为疼痛模型，以消炎痛肠溶片为阳性对照药，观察芫花根总黄酮对大鼠痛阈、疼痛级别以及炎症局部组织中前列腺素E2(PGE2)、超氧化物歧化酶(SOD)的影响。结果芫花根总黄酮可使佐剂性关节炎大鼠痛阀增加和疼痛级别降低，显著减少炎症组织中PGE2含量。提升炎症组织中SOD的活力，并且芫花根总黄酮的作用强度和消炎痛肠溶片类似。结论芫花根总黄酮具有较好的镇痛效果，其机制可能和抑制PGE2生成，提升SOD活力有关。 |
| 关 键 词： | 芫花根总黄酮 镇痛 作用机制 痛阈 疼痛级别 前列腺素E2 超氧化物歧化酶 |
| 文章编号： | 1001-5949(2005)01-0021-03 |
| 修稿时间： | 2004年6月15日 |
The study on the analgesic effects and mechanism of the total flavonoids from Daphne genkwa Sieb et. Zucc |
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| WANG Li,et al..The study on the analgesic effects and mechanism of the total flavonoids from Daphne genkwa Sieb et. Zucc[J].Ningxia Medical Journal,2005,27(1):21-23. | |
| Authors: | WANG Li |
| Abstract: | Objective To investigate the analgesic activities of DTF, and discuss the analgsic mechanism of the total flavonoids of Daphne genkwa.Methods Adopting adjuvant arthrititis(AA) model by freund's complete adjuvant, the influence of DTF on pain-threshold, the nociceptive level, the content of PGE 2, the activity of SOD were observed, compared with indomethacin.Results DTF evidently increased pain-threshold, debased the nociceptive level, inhibited the production of PGE 2,enhanced the activity of SOD in AA rats,and the analgesic effects of DTF was similar to that of indomethacin in our experiment.Conclusion DTF were one of the major components suppressing pain and its mechanism may be related to decreasing the product of PGE 2, as well as enhancing the activity of SOD |
| Keywords: | The total flavonoids of daphne genkwa The analgesic activities The analgsic mechanism Pain-threshold The nociceptive level PGE 2 SOD |
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