孟鲁司特钠联合青霉素钠治疗儿科呼吸系统反复感染的临床疗效分析

目的 探讨呼吸系统反复感染患儿给予孟鲁司特钠联合青霉素钠的治疗效果及对炎性细胞因子水平与肺功能的影响。方法 选取2019年12月至2020年12月延安大学附属医院儿科收治的80例呼吸系统反复感染患儿,按随机数字表分为两组,各40例。对照组单一青霉素钠治疗,观察组青霉素钠+孟鲁司特钠治疗,观察两组临床疗效、炎性因子、肺功能以及不良反应等指标水平变化情况。结果 治疗后,观察组总有效率为95.00%,较对照组（77.50%）高;观察组白介素-2（interleukin-2,IL-2）、白介素-4（interleukin-4,IL-4）、肿瘤坏死因子-α（tumor necrosis factor-α,TNF-α）、干扰素-γ（interferon-gamma,IFN-γ）等炎性细胞因子水平均优于对照组;第1秒用力呼气容积（forced expiratory volume in the first second,FEV1）、用力肺活量（forced vital capacity,FVC）及FEV1/FVC等肺功能水平均高于对照组;观察组不良反应总发生率为5.00%,显著低于对照组（20.00%）,各指标差异均有统计学意义（P<0.05）。结论 呼吸系统反复感染患儿临床治疗中选用青霉素钠+孟鲁司特钠治疗方案,可明显改善患者炎性因子水平与肺功能,且不良反应发生率较低,治疗效果显著。

Clinical efficacy of montelukast sodium combined with penicillin sodium in the treatment of pediatric recurrent respiratory infection

Objective To investigate the effect of montelukast sodium combined with penicillin sodium on the level of inflammatory factors and pulmonary function in children with recurrent respiratory infection. Methods 80 children with recurrent respiratory infection from December 2019 to December 2020 were divided into two groups according to the table of random numbers, 40 cases in each group. The control group was treated with single penicillin sodium and the observation group was treated with penicillin sodium and montelukast sodium. The changes of clinical efficacy, inflammatory factors, pulmonary function and adverse reactions were observed. Results The total effective rate of the observation group was 95.00% , which was higher than that of the control group （77.50% , P<0.05）. The levels of interleukin-2（IL-2） , interleukin-4（IL-4） , tumor necrosis factor-?α（TNF-?α） and interferon-gamma （IFN-γ） in the observation group were significantly higher than those in the control group （P<0.05）. The forced expiratory volume in the first second （FEV1）, forced vital capacity （FVC） and FEV1/FVC were significantly higher than those in the control group. The total incidence of adverse reactions in the observation group was 5.00%, which was significantly lower than that in the control group （20.00%）, and the differences in each index were statistically significant （P<0.05）. Conclusion In the clinical treatment of children with recurrent respiratory infection, the penicillin sodium + montelukast sodium treatment plan can significantly improve the level of inflammatory factors and lung function, reduce the incidence of adverse reactions, and have a significant curative effect.