产前IgG血型抗体效价与新生儿ABO溶血病病例分析

目的 分析产前免疫球蛋白G(IgG)血型抗体效价与新生儿ABO溶血病的临床资料,探究不同IgG血型抗体效价中新生儿ABO溶血病的发生情况。方法 回顾性分析延安大学附属医院2018年1月至2020年12月期间行产前IgG血型抗体效价检测的孕妇200例的临床资料,统计不同产前IgG血型抗体效价中新生儿ABO溶血病的发生情况。结果 经临床统计,200例孕妇中,抗体效价≤1∶64共有100例,占比率为50.00%,其中抗体效价＜1∶64的有52例,占比26.00%,抗体效价为1∶64的共有48例,占比为24.00%;抗体效价为1∶128共有37例,占比18.50%;抗体效价在1∶256共有44例,占比22.00%;抗体效价≥1∶512共有19例,占比9.50%;随着产前IgG血型抗体效价升高,其新生儿ABO溶血病发病率也逐渐增长,发病率由低至高依次为1.92%、12.50%、40.54%、50.00%、68.42%。结论 新生儿ABO溶血病的发生率随着产前IgG血型抗体效价的升高而逐渐增高,其中产前IgG血型抗体效价≥1∶512的孕妇,新生儿ABO溶血病发生率最高。

Case analysis of antenatal IgG blood group antibody titer and neonatal ABO hemolytic disease

Objective To analyze the clinical data of prenatal immunoglobulin G (IgG) blood group antibody titer and neonatal ABO hemolytic disease,and explore the occurrence of neonatal ABO hemolytic disease in different IgG blood type antibody titer. Methods The clinical data of 200 pregnant women who underwent prenatal IgG blood group antibody titer testing from January 2018 to December 2020 in the Affiliated Hospital of Yan'an University were retrospectively analyzed.The incidence of neonatal ABO hemolytic disease in different antenatal IgG blood group antibody titers was counted. Results According to clinical statistics,among 200 pregnant women,100 cases had an antibody titer ≤1∶64,among them,52 cases had an antibody titer of less than 1∶64,accounting for 26.00%,and a total of 48 cases had an antibody titer of 1∶64,accounting for 24.00%.The antibody titer was 1∶128 in 37 cases,accounting for 18.50%.There were 44 cases with antibody titer of 1∶256,accounting for 22.00%.There were 19 cases with antibody titer ≥ 1∶512,accounting for 9.50%.With the increase of antenatal IgG blood group antibody titer,the incidence of neonatal ABO hemolytic disease has gradually increased,with the incidence of 1.92%,12.50%,40.54%,50.00%,and 68.42% from low to high. Conclusion The incidence of neonatal ABO hemolytic disease gradually increases with the increase of antenatal IgG blood group antibody titer.Among them,pregnant women with prenatal IgG blood group antibody titer ≥ 1∶512 have the highest incidence of neonatal ABO hemolytic disease.