| 白藜芦醇甙对大鼠急性肺损伤模型的保护机制 |
| |
| 引用本文： | 申美霞,王少华,熊淑英,王兴勇.白藜芦醇甙对大鼠急性肺损伤模型的保护机制[J].南华大学学报(医学版),2006,34(1):18-20. |
| |
| 作者姓名： | 申美霞 王少华 熊淑英 王兴勇 |
| |
| 作者单位： | 1. 深圳市福田区妇幼保健院,儿科,广东,深圳,518026
2. 重庆医科大学,儿科学院 |
| |
| 基金项目： | 广东省深圳市福田区科技局立项项目 |
| |
| 摘 要： | 目的研究白藜芦醇甙（PD）对休克大鼠肺损伤的干预机制.方法将休克性肺损伤大鼠随机分为4组：单纯手术组、内毒素休克组、PD预防组和PD治疗组,检测肺系数、肺组织肺通透指数（LPI）、肺泡灌洗液（BALF）中蛋白含量及磷脂酶A2（PLA2）活性,观察肺组织病理切片.结果 PD预防组和治疗组中LPI、BALF中蛋白含量、PLA2较对照组明显降低;PD可明显减轻内毒素休克性肺损伤的程度.结论白藜芦醇甙对大鼠内毒素休克性肺损伤具有保护作用,且预防性用药效果更佳.
|
| 关 键 词： | 休克 内毒素 肺损伤 白藜芦醇甙 |
| 文章编号： | 1672-7444（2006）01-0018-03 |
| 收稿时间： | 2005-10-10 |
| 修稿时间： | 2005年10月10 |
Protective Effects of Polydatin on Injury Following Endotoxic Shock in Rats |
| |
| SHEN Mei - xi,WANG Shao - hu,XIONG Shu - ying,et al.Protective Effects of Polydatin on Injury Following Endotoxic Shock in Rats[J].Journal of Nanhua University(Medical Edition),2006,34(1):18-20. |
| |
| Authors: | SHEN Mei - xi WANG Shao - hu XIONG Shu - ying |
| |
| Institution: | NICU Women and Children Health Institute Futian, Shenzhen, Guangdong 518026, China |
| |
| Abstract: | Objective To investigate the interfered effects of Polydatin on endotoxic shock-induced lung injury in rats. Methods The endotoxic shock model of rats were randomly divided into 4 groups as sham operation group,endotoxic shock group,Polydatin treatment group and Polydatin pretreatment group.The lung coefficient(LC),the lung penetrated index(LPI),protein content of BALF and the activity of PLA_2 were determined.Results The activity of PLA_2,LC,LPI and protein content of BALF in Polydatin treatment groups were lower than those in sham operation groups.The degree of endotoxic shock-induced lung injury can be eased by Polydatin.Conclusion The protection effect of Polydatin on acute lung injury is remarkable,and the prophylactic effect is better than the therapeutical effects. |
| |
| Keywords: | shock endotoxin lung injury Polydatin |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
| 点击此处可从《南华大学学报(医学版)》浏览原始摘要信息 |
| 点击此处可从《南华大学学报(医学版)》下载免费的PDF全文 |
|
