| EB病毒gp350/220抗原T-B联合表位生物信息学预测 |
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| 引用本文： | 彭菁,李蓓,吴移谋. EB病毒gp350/220抗原T-B联合表位生物信息学预测[J]. 南华大学学报(医学版), 2020, 0(3): 292-296 |
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| 作者姓名： | 彭菁 李蓓 吴移谋 |
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| 作者单位： | 南华大学附属第二医院,湖南 衡阳 421001;南华大学衡阳医学院病原生物学研究所, 湖南 衡阳 421001 |
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| 摘 要： | 为预测EB病毒(EBV)gp350/220抗原T-B联合表位,采用在线软件IEDB和SYFPEITHIT分别预测gp350/220抗原B细胞表位和T细胞表位,寻找该抗原B细胞和T细胞共同的区域即T-B联合表位。gp350/220抗原存在潜在的T-B联合表位区域:28-43、49-55、59-64、69-79、85-91、99-111、119-129、135-144。本文运用生物信息学方法确定了gp350/220分别存在5个T细胞抗原表位﹑6个B细胞表位和3个T-B细胞联合表位区域,为进一步研发gp350/220高价优势表位疫苗奠定基础。
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| 关 键 词： | gp350/220 T-B联合表位 生物信息学 |
| 收稿时间： | 2020-02-19 |
| 修稿时间： | 2020-03-26 |
Bioinformatics prediction of T-B combined epitope of EB virus gp350/220 antigen |
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| PENG Jing,LI Bei,WU Yimou. Bioinformatics prediction of T-B combined epitope of EB virus gp350/220 antigen[J]. Journal of Nanhua University(Medical Edition), 2020, 0(3): 292-296 |
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| Authors: | PENG Jing LI Bei WU Yimou |
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| Affiliation: | The Second Affiliated Hospital of South China,Hengyang 421001,Hunan,China; Institution of Pathogenic Biology,Medical College,University of South China,Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study,Hengyang 421001,Hunan,China |
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| Abstract: | To predict T-B united epitope of EB gp350/220, B cell epitopes and T cell epitopes of antigen gp350/220 were predicted using the online software IEDB and SYFPEITHIT, respectively, to define the common area of B cell and T cell epitopes, namely the T-B combined epitopes of the antigen. There were potential T-B combined epitopes of antigen gp350/220:28-43,49-55,59-64,69-79,85-91,99-111,119-129,135-144. In this paper, bioinformatics methods were used to determine the presence of five T-cell epitopes, six B-cell epitopes, and three TB-cell joint epitope regions in gp350/220, laying a foundation for the further development of gp350/220 high-priority epitope vaccines. |
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| Keywords: | gp350/220 T-B united epitope bioinformatics |
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