分析RhE抗原分布检测对临床输血的价值

分析恒河猴E抗原(RhE)分布检测对临床输血的价值,为临床实践提供参考。对本院临床住院及献血人员恒河猴D抗原(RhD)血液样本16 800例进行RhE、e表型鉴定分析,并分析其中2 280例RhE阴性接收RhE阳性血液后不规则抗体的变化,分析患者输血前后血液指标的变化情况。结果显示16 800例RhD血液样本Dee、DEe及DEE表型分别为8 420(50.1%)、6 847(40.8%)和1 533(9.1%)；RhE阴性患者接收RhE阳性血液后不规则抗体分析发现产生阳性抗体共有185例,占8.1%,且两组患者输血前后胆红素及网织红细胞无明显变化,而3次及以上输血患者输血后血红蛋白(Hb)及红细胞(RBC)明显升高(P<0.05)。因此,RhE抗原分布检测指导临床同型输血具有重要的价值。

The value analysis of RhE antigen distribution detection for clinical transfusion

To analyz the value of RhE antigen distribution in clinical transfusion in order to provide reference for clinical practice.The RhE and E phenotypes of 16 800 RhD blood samples from 2010 to 2017 in our hospital were analyzed.The changes of irregular antibody after RhE negative receiving RhE positive blood were analyzed in 2 280 cases.The changes of blood indexes before and after blood transfusion were analyzed.The results showed the phenotypes of Dee, DEe, and DEE in 16 800 RhD blood samples were 8 420 (50.1%), 6847 (40.8%) and 1 533 (9.1%), respectively.The analysis of irregular antibody after receiving RhE positive blood in RhE negative patients found that there were 185 cases of positive antibodies, which accounted for 8.1%.There was no significant change in bilirubin and reticulocyte in two groups before and after blood transfusion, while Hb and RBC increased significantly after transfusion for 3 times or more (P<0.05).So the detection of RhE antigen distribution is of great value in guiding clinical Homo blood transfusion.