| 姜黄素对巨噬细胞源性荷脂细胞胆固醇水平及caveolin-1表达的影响 |
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| 引用本文： | 李熠,匡双玉,王北冰,尹凯,沈元琼,桂庆军.姜黄素对巨噬细胞源性荷脂细胞胆固醇水平及caveolin-1表达的影响[J].南华大学学报(医学版),2009,37(1):18-20. |
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| 作者姓名： | 李熠 匡双玉 王北冰 尹凯 沈元琼 桂庆军 |
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| 作者单位： | 1. 南华大学,医学院,诊断学教研室,湖南,衡阳,421001
2. 南华大学,第二附属医院,药剂科 |
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| 基金项目： | 湖南省科技厅课题，湖南省卫生厅资助课题 |
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| 摘 要： | 目的观察姜黄素对巨噬细胞源性荷脂细胞胆固醇水平的影响，并初步探讨caveolin-1蛋白表述在其中的作用。方法实验分组分为正常巨噬细胞组、巨噬细胞源性荷脂细胞组和姜黄素处理组。3组均采用油红O染色检测细胞荷脂情况，高效液相色谱分析法检测细胞内胆固醇含量，Western印迹法检测caveolin-1蛋白的表达。结果姜黄素作用于巨噬细胞源性荷脂细胞，细胞内总胆固醇、游离胆固醇和胆固醇酯含量均下降；caveolin-1蛋白表达上调。结论姜黄素引起巨噬细胞源性荷脂细胞胆固醇含量下降的同时，caveolin—1蛋白表达上调。
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| 关 键 词： | 姜黄素 巨噬细胞 荷脂细胞 胆固醇 caveolin-1 |
The Effect of Curcumin on the Cholesterol Metabolism and the Expression of Caveolin-1 in Macrophage-derived Cholesterol-load Cell |
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| LI Yi,KUANG Shuang-yu,WANG Bei-bing,et al.The Effect of Curcumin on the Cholesterol Metabolism and the Expression of Caveolin-1 in Macrophage-derived Cholesterol-load Cell[J].Journal of Nanhua University(Medical Edition),2009,37(1):18-20. |
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| Authors: | LI Yi KUANG Shuang-yu WANG Bei-bing |
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| Institution: | LI Yi,KUANG Shuang-yu,WANG Bei-bing,et al (Department of Diagnosis,Medical College,University of South China,Hengyang,Hunan 421001,China) |
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| Abstract: | Objective To observe the effect of curcumin on the cholesterol metabolism in macrophage-derived cholesterol-load cell,and to investigate the effect of the expression of caveolin-1 in this process. Methods Three groups are designed in the experimrnt as follows: the normal macrophage group,the macrophage-derived cholesterol-load cells group and the macrophage-derived cholesterol-load cells group effected by curcumin.Rathonum red stain and high performance liquid phase analytic process are used to assess and d... |
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| Keywords: | caveolin-1 |
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