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痹肿消汤对实验性关节炎大鼠血浆TNF-α及IL-1β的影响
引用本文:王安宇,梁清华,陈疆,罗徐,李春燕,包大成,汤天凤,谭勇.痹肿消汤对实验性关节炎大鼠血浆TNF-α及IL-1β的影响[J].中南大学学报(医学版),2004,29(3):266-266.
作者姓名:王安宇  梁清华  陈疆  罗徐  李春燕  包大成  汤天凤  谭勇
作者单位:中南大学湘雅医院1.中西医结合研究所; 2.远程医疗中心,长沙 410008
基金项目:湖南省科技基金 (0 2ssy40 2 8),湖南中医管理局基金 (2 0 0 53),国家自然科学基金 (30 371 833)
摘    要:目的:观察痹肿消汤(bizhongxiao decotion, BZXD)对实验性关节炎大鼠血浆肿瘤坏死因子α(tumornecrosis factorα,TNF-α)和白细胞介素-1β(interleukin-1β,IL-1β)的影响,探讨痹肿消汤治疗类风湿性关节炎(rheumatoid arthritis,RA)的作用机制。方法:75只SD大鼠随机分为4组,皮下注射Ⅱ型胶原诱导实验性关节炎模型,采用放射免疫法检测各组大鼠不同时间血浆TNF-α和IL-1β水平。结果:造模大鼠88%出现关节炎症状;造模25d后,模型组、痹肿消汤组及甲氨喋呤组大鼠TNF-α和IL-1β水平明显高于正常组(P<0.05);且模型组TNF-α和IL-1β水平明显高于痹肿消汤组及甲氨喋呤组(P<0.01);随着时间延长,模型组TNF-α和IL-1β水平逐渐升高,痹肿消汤组及甲氨喋呤组则逐渐降低;而痹肿消汤组TNF-α和IL-1β水平低于甲氨喋呤组(P<0.05)。结论:TNF-α和IL-1β在RA滑膜组织炎症形成和发展中发挥着重要作用;痹肿消汤与甲氨喋呤均能下调血浆TNF-α和IL-1β水平,但痹肿消汤的作用优于甲氨喋呤。

关 键 词:痹肿消汤  甲氨喋呤  关节炎  类风湿性  TNF-&alpha  IL-1&beta  大鼠  
文章编号:1672-7347(2004)03-0266-04
收稿时间:2003-11-13
修稿时间:2003年11月13

Effect of bizhongxiao decotion on TNF-α and interleukin-1β in plasma of rats with CⅡ-induced rheumatoid arthritis
WANG An-yu ,LIANG Qing-hua ,CHEN Jiang ,LUO Xu ,LI Chun-yan ,BAO Da-cheng ,TANG Tian-feng ,TAN Yong.Effect of bizhongxiao decotion on TNF-α and interleukin-1β in plasma of rats with CⅡ-induced rheumatoid arthritis[J].Journal of Central South University (Medical Sciences)Journal of Central South University (Medical Sciences),2004,29(3):266-266.
Authors:WANG An-yu  LIANG Qing-hua    CHEN Jiang  LUO Xu  LI Chun-yan  BAO Da-cheng  TANG Tian-feng  TAN Yong
Institution:1.Institute of Combined Traditional Chinese and Western Medicine; 2.Xiangya Telemedicine Centre, Xiangya Hospital, Central South University, Changsha 410008, China
Abstract:OBJECTIVE: To observe the influence of bizhongxiao decotion (BZXD) on the plasma TNF-alpha and IL-1beta in rats with C II-induced arthritis (CIA) and to explore the mechanism of BZXD in the treatment of rheumatoid arthritis. METHODS: We divided 75 rats into 4 groups randomly. The rat experimented arthritis model was established by subcutaneous injection with collagen II. The plasma TNF-alpha and IL-1beta levels were detected with the radio-immunity assay at different time spots. RESULTS: The incidence of arthritis in the rats immunized with C II was approximately 88%. The plasma TNF-alpha and IL-1beta levels of the model group, BZXD group and methotrexate (MTX) group were notably higher than those of the normal group (P < 0.05). The plasma TNF-alpha and IL-1beta levels of the model group were higher than those of the MTX control group and BZXD treatment group at different time spots (P < 0. 01). The plasma TNF-alpha and IL-1beta levels rose step by step, but those of the BZXD group and MTX group decreased gradually. Moreover, the plasma TNF-alpha and IL-1beta levels of the rats of BZXD group were lower than those of the MTX group (P < 0. 05). CONCLUSION: TNF-alpha and IL-1beta play a very important role in the formation and development of rheumatoid arthritis. Both BZXD and MTX can notably decrease the plasma TNF-alpha and IL-1beta levels, but the effect of BZXD is better than that of MTX.
Keywords:bizhongxiao decotion  methotrexate  arthritis  rheumatoid  TNF-α  IL-1β  rats
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