中枢神经系统感染性疾病的病原学研究

目的 :探讨中枢神经系统感染性疾病的病原学特点。方法 :分别用双抗体夹心ELISA法和传统的细菌及真菌培养等方法检测患者血清IgM ,IgG抗体和脑脊髓液中病原体。结果 :82 3例中枢神经系统急症患者中有 12 6例 (15 .3%)单纯疱疹病毒IgM和 /或IgG阳性 ,其中 10岁以下年龄为高峰。 10 (1.2 %)例巨细胞病毒特异性IgM和 /或IgG阳性 ;8(0 .97%)例水痘 带状疱疹病毒特异性IgM和 /或IgG阳性 ;7(0 .85 %)例为结核性脑膜炎 ;6 (0 .72 %)例为新生隐球菌性脑膜炎 ;1(0 .12 %)例为脑膜炎球菌性脑膜炎。结论 :病毒 ,特别是单纯疱疹病毒 ,是中枢神经系统感染性疾病的常见病原 ;结核杆菌和新生隐球菌感染也占一定比例。

Etiology of infectious diseases in the central nervous system

Objective To determine the etiological characteristics of infectious diseases in the central neural system(CNS) . Methods The serum and cerebral spinal fluid of acute patients in the CNS were detected for virus-specific IgM ,IgG and pathogens with enzyme-linked immunosorbent assay as well as traditional bacterial and fungal culture.Results Of the 823 patients,126 (15.3%) patients were positive herpes simplex virus(HSV)-specific IgM and/or IgG, of which the maximum morbidity was under 10 years;10(1.2%) were positive cytomegalovirus specific IgM and/or IgG;8(0.97%)were positive varicella-zoster virus specific IgM and/or IgG; 7(0.85%) were diagnosed as tubercular meningitis; 6(0.72%) as cryptocococcs meningitis and 1(0.12%) as meningococcic meningitis.Conclusion Viruses,especially herpes simplex viruses are the common causative agents of infectious diseases of the CNS, in which mycobacterium tuberculosis and cryptocococcus neoformans are conspicuous.