| 应用cDNA微阵列技术研究MMP1,TIMP1基因在肺癌中的表达 |
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| 引用本文： | 欧阳取长,胡成平,梁清华,石林阶,吴鄂生,杨红忠,潘频华.应用cDNA微阵列技术研究MMP1,TIMP1基因在肺癌中的表达[J].中南大学学报(医学版),2003,28(3):227-228. |
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| 作者姓名： | 欧阳取长 胡成平 梁清华 石林阶 吴鄂生 杨红忠 潘频华 |
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| 作者单位： | 1. 中南大学湘雅医院呼吸科,长沙410008
2. 中南大学湘雅医院中西医结合研究所,长沙410008 |
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| 摘 要： | 研究基质金属蛋白酶 1 (MMP1 )和基质金属蛋白酶组织抑制物 1 (TIMP1 )基因在肺鳞癌、肺腺癌中的表达。方法 :利用含 4 0 96个基因的cDNA微阵列检测肺鳞癌、肺腺癌组织与正常肺组织的差异表达基因 ,重点分析MMP1 ,TIMP1在肺鳞癌与肺腺癌中的表达。结果 :MMP1 ,TIMP1基因在肺鳞癌与肺腺癌中均表达上调。结论 :MMP1 ,TIMP1在肺鳞癌、肺腺癌中均出现表达上调 ,可作为肺鳞癌、肺腺癌的重要分子标记
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| 关 键 词： | 微阵列 MMP1 TIMP1 基因表达 |
| 文章编号： | 1000-5625(2003)03-0227-02 |
| 修稿时间： | 2002年12月17 |
Gene expression of MMP1 and TIMP1 in lung cancer detected with a cDNA microarray technique |
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| OUYANG Qu chang ,HU Cheng ping ,LIANG Qing hua ,et al..Gene expression of MMP1 and TIMP1 in lung cancer detected with a cDNA microarray technique[J].Journal of Central South University (Medical Sciences)Journal of Central South University (Medical Sciences),2003,28(3):227-228. |
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| Authors: | OUYANG Qu chang HU Cheng ping LIANG Qing hua |
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| Institution: | (1.Department of Respiration; 2.Institute of Combined Traditional Chinese Medicine and Western Medicine, Xiangya Hospital,Central South University,Changsha 410008,China) |
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| Abstract: | Objective To investigate the gene expression of matrix metalloproteinases 1( MMP 1) and tissue inhibitors of matrix metalloprotainases 1( TIMP 1) in squmas cell lung cancer and adenocarcinoma .Methods Gene expression profile cDNA microarray cgntaining 4 096 genes was used to identify differentially expressed genes in squmas cell lung cancer and adenocarcinoma,and to analyze the gene expression of MMP1 and TIMP 1.Results Gene MMP1 and TIMP 1 were differentially expressed in both squmas cell lung cancer and adenocarcinoma,and both of them were up regulated. Conclusion MMP 1 and TIMP 1 may be important molecular markers of squmas cell lung cancer and adenocarcinoma. |
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| Keywords: | gene expression matrix metalloproteinases 1 tissue inhibitors of matrix metalloprotainases 1 cDNA microarrays |
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