IL-2,IL-7,IL-15和IL-21在艾滋病免疫疗法中的应用前景

高效抗反转录病毒疗法可以有效地减少HIV的复制,但却不能完全恢复CD4+T细胞的数量.即使病毒血清学指标得到良好控制的病人,CD4+T细胞数也很难达到正常水平.目前研究表明:γ链细胞因子在始动、维持及调节免疫稳态和炎症反应中发挥重要作用.γ链细胞因子具有多重功能,如在健康及疾病中作为调节和效应分子发挥作用,因此,该家族...

Prospect of IL-2, IL-7, IL-15 and IL-21 for HIV immune-based therapy

Although highly active antiretroviral therapy (HAART) can effectively reduce the HIV replication,complete recovery of CD4+ T cells does not always occur,even among patients with high virological control.Current researches on γ-chain cytokines have understood the biology and their crucial roles in initiating,maintaining,and regulating the immunologic homeostasis and the inflammatory processes.Due to the multiple functions such as the regulatory and effector cellular function in healthy and disease state,these molecules,their receptors,and their signal transduction pathways are promising candidates for therapeutic interference.The common γ-chain cytokines IL-2,IL-7,IL-15,and IL-21 are primary regulators of T cell homeostasis and thus have been considered prime immunotherapeutic candidates,both for increasing T cell levels/function and augmenting vaccine-elicited viral-specific T cell responses in immunocompromised AIDS patients.The objective of this review is to update the role of the common γ-chain cytokines IL-2,IL-7,IL-15,and IL-21 in HIV AIDS pathogenesis.