血管内皮生长因子在鼻咽癌中的表达及其临床意义

目的 :探讨血管内皮生长因子 (VEGF)在鼻咽癌 (NPC)中的表达特点及其临床意义。方法 :应用免疫组织化学S P法对 47例低分化NPC及 10例慢性鼻咽炎患者进行VEGF蛋白产物检测 ,并进行 5年以上随访观察。结果 :① 47例NPC组织中 32例 ( 6 8.0 %)VEGF蛋白表达阳性。 10例慢性鼻咽炎上皮VEGF表达均为阴性 ;②伴颈淋巴结转移的NPC组织中VEGF表达阳性率 ( 82 .6 %) ,明显高于不伴颈部淋巴结转移者 ( 5 4.2 %,P <0 .0 5 ) ;③NPC放疗后局部复发者VEGF阳性表达率 ( 85 .0 %) ,明显高于无局部复发者 ( 5 5 .5 %,P <0 .0 5 ) ;④NPC放疗后 <5年生存期者VEGF阳性表达率 ( 84.2 %) ,明显高于≥ 5年生存期者 ( 6 4.3%,P <0 .0 5 ) ;⑤Ⅲ～Ⅳ期NPC组织中VGEF的表达阳性率 ( 80 .0 %)明显高于Ⅰ～Ⅱ期表达阳性率 ( 49.0 %,P <0 .0 5 )结论 :VEGF蛋白过度表达可能在NPC发生、发展过程中起一定作用 ,检测VEGF在NPC组织中的表达对预测NPC颈淋巴转移和复发、临床分期及评估预后有一定意义。

Expression and clinical significance of vascular endothelial growth factor in nasopharyngeal carcinoma

Objective To evaluate the expression of vascular endothelial growth factor (VEGF) in nasopharyngeal carcinoma (NPC) and its clinical significance. Methods The expression of VEGF in the 47 NPC and 10 chronic nasopharngotis tissues was examined by an immunohistochemical S-P method. Results ① The positive rate of VEGF was 68.0%(32/47) in NPC tissues, but VEGF protein was not detected in chronic nasopharngotis tissues.②The VEGF positive rate of NPC with lymph node metastasis was significantly higher than that of NPC without lymph node metastasis (82.6%vs. 54.2%,P< 0.05).②The VEGF positive rate of recurrent NPC was significantly higher than that without recurrent NPC ( 85.0% vs.55.5%,P < 0.05). ④The VEGF positive rate of the less than 5-year survival after a radiotherapy in the NPC patients was significantly higher than that of the more than 5-year ones in the chronic nasopharyngotis patients (84.2%vs. 64.3%,P<0.05). ⑤The VEGF positive rate of NPC tissues with the Stage Ⅲ～Ⅳ was significantly higher than that with the Stage Ⅰ～Ⅱ (80.0%vs. 49.0%,P<0.05). Conclusion The overexpression of VEGF may play a role in the pathogenesis of NPC and the detection of VEGF protein in the NPC tissues may be useful for calculating the lymph node metastasis and recurrence,judging the clinical stages,and evaluating the prognose of NPC.